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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
4.55
Human Site:
S31
Identified Species:
7.14
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S31
G
P
H
D
I
G
A
S
P
G
D
K
K
S
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Dog
Lupus familis
XP_852722
879
98718
K34
G
A
S
P
G
D
K
K
S
K
N
K
S
A
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S31
G
P
S
A
V
G
A
S
P
G
D
K
K
S
K
Rat
Rattus norvegicus
Q5U2P0
1054
120741
Q40
C
N
S
P
L
C
P
Q
P
A
T
C
R
N
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
K31
V
P
T
S
G
D
R
K
N
R
N
K
P
A
R
Frog
Xenopus laevis
Q6GN11
1040
119148
L46
T
C
P
R
D
G
K
L
L
S
E
E
L
T
H
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
L113
D
P
R
H
D
C
V
L
F
A
N
E
F
Q
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
E31
D
R
D
C
R
R
I
E
G
L
R
Q
R
S
Q
Honey Bee
Apis mellifera
XP_624734
786
91013
N31
H
K
I
S
K
N
K
N
K
G
I
S
Q
S
S
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
I33
N
N
F
N
P
R
K
I
F
T
E
Y
I
S
K
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
E31
A
V
Q
I
L
T
G
E
V
V
M
T
P
K
S
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
P43
E
P
I
V
G
G
G
P
H
G
K
L
L
P
F
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
P129
P
R
A
C
E
Q
S
P
G
M
N
G
E
L
F
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
T177
N
D
R
A
I
R
K
T
C
Q
W
Y
S
E
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
13.3
N.A.
80
6.6
N.A.
N.A.
13.3
6.6
6.6
N.A.
6.6
13.3
13.3
0
P-Site Similarity:
100
N.A.
0
33.3
N.A.
86.6
26.6
N.A.
N.A.
33.3
26.6
26.6
N.A.
26.6
26.6
26.6
6.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
20
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
20
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
7
14
0
0
14
0
0
14
0
0
0
14
0
% A
% Cys:
7
7
0
14
0
14
0
0
7
0
0
7
0
0
0
% C
% Asp:
14
7
7
7
14
14
0
0
0
0
14
0
0
0
7
% D
% Glu:
7
0
0
0
7
0
0
14
0
0
14
14
7
7
0
% E
% Phe:
0
0
7
0
0
0
0
0
14
0
0
0
7
0
14
% F
% Gly:
20
0
0
0
20
27
14
0
14
27
0
7
0
0
0
% G
% His:
7
0
7
7
0
0
0
0
7
0
0
0
0
0
14
% H
% Ile:
0
0
14
7
14
0
7
7
0
0
7
0
7
0
0
% I
% Lys:
0
7
0
0
7
0
34
14
7
7
7
27
14
7
20
% K
% Leu:
0
0
0
0
14
0
0
14
7
7
0
7
14
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
7
7
0
0
0
0
% M
% Asn:
14
14
0
7
0
7
0
7
7
0
27
0
0
7
0
% N
% Pro:
7
34
7
14
7
0
7
14
20
0
0
0
14
7
0
% P
% Gln:
0
0
7
0
0
7
0
7
0
7
0
7
7
7
14
% Q
% Arg:
0
14
14
7
7
20
7
0
0
7
7
0
14
0
14
% R
% Ser:
0
0
20
14
0
0
7
14
7
7
0
7
14
34
14
% S
% Thr:
7
0
7
0
0
7
0
7
0
7
7
7
0
7
0
% T
% Val:
7
7
0
7
7
0
7
0
7
7
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
14
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _