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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
14.55
Human Site:
S345
Identified Species:
22.86
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S345
T
E
Y
G
V
D
F
S
D
F
S
S
E
V
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
A101
I
F
I
D
G
V
V
A
R
N
R
A
L
N
G
Dog
Lupus familis
XP_852722
879
98718
S343
T
E
Y
G
V
D
F
S
D
F
S
S
E
V
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S343
T
E
Y
G
V
D
F
S
D
F
S
S
E
V
L
Rat
Rattus norvegicus
Q5U2P0
1054
120741
E440
I
N
V
V
P
F
S
E
A
Q
M
C
E
M
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S340
T
E
Y
G
V
D
F
S
D
F
S
P
E
A
L
Frog
Xenopus laevis
Q6GN11
1040
119148
S434
S
I
S
L
N
P
F
S
E
A
Q
L
A
E
M
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
E434
I
H
V
P
P
F
S
E
A
Q
L
R
E
M
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
I534
F
H
N
G
L
R
D
I
K
P
F
E
Q
R
F
Honey Bee
Apis mellifera
XP_624734
786
91013
D306
I
D
P
D
A
A
V
D
L
D
D
S
V
S
C
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
A324
T
A
R
D
L
D
D
A
L
H
A
K
H
I
D
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
L306
S
E
F
T
T
E
V
L
E
D
L
P
K
E
R
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
C366
L
H
E
N
A
I
C
C
S
K
F
S
P
E
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
D450
L
Y
Q
N
S
V
C
D
S
D
F
S
P
G
S
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
R493
L
E
H
D
V
E
Y
R
P
F
S
K
K
V
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
100
N.A.
100
6.6
N.A.
N.A.
86.6
13.3
6.6
N.A.
6.6
6.6
13.3
6.6
P-Site Similarity:
100
N.A.
13.3
100
N.A.
100
13.3
N.A.
N.A.
86.6
33.3
13.3
N.A.
20
13.3
40
40
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
40
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
6.6
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
14
7
0
14
14
7
7
7
7
7
0
% A
% Cys:
0
0
0
0
0
0
14
7
0
0
0
7
0
0
7
% C
% Asp:
0
7
0
27
0
34
14
14
27
20
7
0
0
0
7
% D
% Glu:
0
40
7
0
0
14
0
14
14
0
0
7
40
20
0
% E
% Phe:
7
7
7
0
0
14
34
0
0
34
20
0
0
0
7
% F
% Gly:
0
0
0
34
7
0
0
0
0
0
0
0
0
7
7
% G
% His:
0
20
7
0
0
0
0
0
0
7
0
0
7
0
0
% H
% Ile:
27
7
7
0
0
7
0
7
0
0
0
0
0
7
0
% I
% Lys:
0
0
0
0
0
0
0
0
7
7
0
14
14
0
0
% K
% Leu:
20
0
0
7
14
0
0
7
14
0
14
7
7
0
34
% L
% Met:
0
0
0
0
0
0
0
0
0
0
7
0
0
14
7
% M
% Asn:
0
7
7
14
7
0
0
0
0
7
0
0
0
7
0
% N
% Pro:
0
0
7
7
14
7
0
0
7
7
0
14
14
0
14
% P
% Gln:
0
0
7
0
0
0
0
0
0
14
7
0
7
0
0
% Q
% Arg:
0
0
7
0
0
7
0
7
7
0
7
7
0
7
7
% R
% Ser:
14
0
7
0
7
0
14
34
14
0
34
40
0
7
14
% S
% Thr:
34
0
0
7
7
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
14
7
34
14
20
0
0
0
0
0
7
27
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
27
0
0
0
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _