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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
6.97
Human Site:
S369
Identified Species:
10.95
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S369
T
I
P
P
E
E
F
S
K
R
R
D
L
R
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
K125
E
E
Q
W
K
V
V
K
P
E
N
N
D
K
E
Dog
Lupus familis
XP_852722
879
98718
S367
T
I
P
P
E
E
F
S
K
R
R
D
L
R
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
G367
T
I
P
P
D
E
V
G
K
R
R
D
L
R
K
Rat
Rattus norvegicus
Q5U2P0
1054
120741
E464
V
S
P
K
E
E
Q
E
R
R
D
L
R
S
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
A364
V
I
S
P
G
E
M
A
K
R
R
D
L
R
K
Frog
Xenopus laevis
Q6GN11
1040
119148
D458
Q
V
K
P
E
E
G
D
R
L
D
L
R
E
T
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
S458
M
D
S
N
E
V
S
S
R
R
D
L
R
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
R558
P
I
S
Q
E
D
L
R
Q
R
K
D
L
R
K
Honey Bee
Apis mellifera
XP_624734
786
91013
V330
I
G
V
H
I
S
D
V
T
H
Y
M
E
F
L
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
A348
L
E
I
G
V
H
I
A
D
V
T
F
F
L
K
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
S330
S
Q
R
R
D
L
R
S
E
C
I
F
T
I
D
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
E390
E
V
P
K
D
E
I
E
N
R
K
D
I
R
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
Q474
E
V
P
E
E
E
V
Q
R
R
K
D
L
R
D
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
D517
W
K
A
P
T
K
L
D
D
P
E
A
V
S
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
100
N.A.
80
26.6
N.A.
N.A.
66.6
20
20
N.A.
46.6
0
6.6
6.6
P-Site Similarity:
100
N.A.
26.6
100
N.A.
86.6
33.3
N.A.
N.A.
73.3
33.3
26.6
N.A.
66.6
0
13.3
26.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
33.3
N.A.
N.A.
46.6
13.3
N.A.
P-Site Similarity:
60
N.A.
N.A.
66.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
0
14
0
0
0
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
0
7
0
0
20
7
7
14
14
0
20
47
7
7
14
% D
% Glu:
20
14
0
7
47
54
0
14
7
7
7
0
7
7
7
% E
% Phe:
0
0
0
0
0
0
14
0
0
0
0
14
7
7
0
% F
% Gly:
0
7
0
7
7
0
7
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
7
0
7
0
0
0
7
0
0
0
0
0
% H
% Ile:
7
34
7
0
7
0
14
0
0
0
7
0
7
7
0
% I
% Lys:
0
7
7
14
7
7
0
7
27
0
20
0
0
7
47
% K
% Leu:
7
0
0
0
0
7
14
0
0
7
0
20
40
7
7
% L
% Met:
7
0
0
0
0
0
7
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
0
7
0
0
0
0
7
0
7
7
0
0
7
% N
% Pro:
7
0
40
40
0
0
0
0
7
7
0
0
0
0
0
% P
% Gln:
7
7
7
7
0
0
7
7
7
0
0
0
0
0
0
% Q
% Arg:
0
0
7
7
0
0
7
7
27
60
27
0
20
47
0
% R
% Ser:
7
7
20
0
0
7
7
27
0
0
0
0
0
14
7
% S
% Thr:
20
0
0
0
7
0
0
0
7
0
7
0
7
0
14
% T
% Val:
14
20
7
0
7
14
20
7
0
7
0
0
7
0
0
% V
% Trp:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _