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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
21.82
Human Site:
S385
Identified Species:
34.29
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S385
C
I
F
T
I
D
P
S
T
A
R
D
L
D
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
I141
E
A
A
Y
E
S
D
I
P
E
E
L
C
G
R
Dog
Lupus familis
XP_852722
879
98718
S383
C
I
F
T
I
D
P
S
T
A
R
D
L
D
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S383
C
I
F
T
I
D
P
S
T
A
R
D
L
D
D
Rat
Rattus norvegicus
Q5U2P0
1054
120741
K480
L
V
F
S
I
D
P
K
G
C
E
D
V
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S380
C
I
F
T
I
D
P
S
T
A
K
D
L
D
D
Frog
Xenopus laevis
Q6GN11
1040
119148
K474
L
V
F
S
I
D
P
K
G
C
E
D
V
D
D
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
K474
L
V
F
S
I
D
P
K
G
C
E
D
V
D
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
M574
C
I
F
T
I
D
P
M
T
A
R
D
L
D
D
Honey Bee
Apis mellifera
XP_624734
786
91013
K346
P
L
D
I
Q
V
S
K
R
A
T
T
I
Y
M
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
A364
G
T
E
L
D
K
W
A
S
E
R
G
N
S
T
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
D346
T
T
A
R
D
L
D
D
A
L
H
C
K
A
L
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
S406
C
I
F
T
I
D
P
S
S
A
T
D
L
D
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
S490
C
V
L
T
I
D
P
S
T
A
T
D
L
D
D
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
D533
P
L
L
T
K
R
K
D
L
R
D
K
L
I
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
100
N.A.
100
46.6
N.A.
N.A.
93.3
46.6
46.6
N.A.
93.3
6.6
6.6
0
P-Site Similarity:
100
N.A.
0
100
N.A.
100
66.6
N.A.
N.A.
100
66.6
66.6
N.A.
93.3
20
20
0
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
86.6
N.A.
N.A.
80
13.3
N.A.
P-Site Similarity:
93.3
N.A.
N.A.
86.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
14
0
0
0
0
7
7
54
0
0
0
7
0
% A
% Cys:
47
0
0
0
0
0
0
0
0
20
0
7
7
0
7
% C
% Asp:
0
0
7
0
14
67
14
14
0
0
7
67
0
67
67
% D
% Glu:
7
0
7
0
7
0
0
0
0
14
27
0
0
0
0
% E
% Phe:
0
0
60
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
0
0
0
0
0
0
20
0
0
7
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
40
0
7
67
0
0
7
0
0
0
0
7
7
0
% I
% Lys:
0
0
0
0
7
7
7
27
0
0
7
7
7
0
0
% K
% Leu:
20
14
14
7
0
7
0
0
7
7
0
7
54
0
7
% L
% Met:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% N
% Pro:
14
0
0
0
0
0
67
0
7
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
7
0
7
0
0
7
7
34
0
0
0
7
% R
% Ser:
0
0
0
20
0
7
7
40
14
0
0
0
0
7
0
% S
% Thr:
7
14
0
54
0
0
0
0
40
0
20
7
0
0
7
% T
% Val:
0
27
0
0
0
7
0
0
0
0
0
0
20
0
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _