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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3L2 All Species: 21.82
Human Site: S385 Identified Species: 34.29
UniProt: Q8IYB7 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IYB7 NP_689596.4 885 99210 S385 C I F T I D P S T A R D L D D
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001114025 580 64957 I141 E A A Y E S D I P E E L C G R
Dog Lupus familis XP_852722 879 98718 S383 C I F T I D P S T A R D L D D
Cat Felis silvestris
Mouse Mus musculus Q8CI75 870 97756 S383 C I F T I D P S T A R D L D D
Rat Rattus norvegicus Q5U2P0 1054 120741 K480 L V F S I D P K G C E D V D D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_422741 859 96810 S380 C I F T I D P S T A K D L D D
Frog Xenopus laevis Q6GN11 1040 119148 K474 L V F S I D P K G C E D V D D
Zebra Danio Brachydanio rerio A2RV18 1057 120333 K474 L V F S I D P K G C E D V D D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_728490 1044 118207 M574 C I F T I D P M T A R D L D D
Honey Bee Apis mellifera XP_624734 786 91013 K346 P L D I Q V S K R A T T I Y M
Nematode Worm Caenorhab. elegans Q09568 817 93710 A364 G T E L D K W A S E R G N S T
Sea Urchin Strong. purpuratus XP_001188256 807 90270 D346 T T A R D L D D A L H C K A L
Poplar Tree Populus trichocarpa XP_002302251 860 96450 S406 C I F T I D P S S A T D L D D
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_177891 1055 116824 S490 C V L T I D P S T A T D L D D
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 D533 P L L T K R K D L R D K L I C
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 63.9 89.4 N.A. 85.9 26 N.A. N.A. 70.4 25.5 25.5 N.A. 29.2 30.3 38.8 43
Protein Similarity: 100 N.A. 64.5 94.1 N.A. 91.5 43.3 N.A. N.A. 82.3 43.2 42.1 N.A. 46 49.9 58.8 57.8
P-Site Identity: 100 N.A. 0 100 N.A. 100 46.6 N.A. N.A. 93.3 46.6 46.6 N.A. 93.3 6.6 6.6 0
P-Site Similarity: 100 N.A. 0 100 N.A. 100 66.6 N.A. N.A. 100 66.6 66.6 N.A. 93.3 20 20 0
Percent
Protein Identity: 33.9 N.A. N.A. 30.2 28.3 N.A.
Protein Similarity: 49.9 N.A. N.A. 46 44.7 N.A.
P-Site Identity: 86.6 N.A. N.A. 80 13.3 N.A.
P-Site Similarity: 93.3 N.A. N.A. 86.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 14 0 0 0 0 7 7 54 0 0 0 7 0 % A
% Cys: 47 0 0 0 0 0 0 0 0 20 0 7 7 0 7 % C
% Asp: 0 0 7 0 14 67 14 14 0 0 7 67 0 67 67 % D
% Glu: 7 0 7 0 7 0 0 0 0 14 27 0 0 0 0 % E
% Phe: 0 0 60 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 7 0 0 0 0 0 0 0 20 0 0 7 0 7 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 0 40 0 7 67 0 0 7 0 0 0 0 7 7 0 % I
% Lys: 0 0 0 0 7 7 7 27 0 0 7 7 7 0 0 % K
% Leu: 20 14 14 7 0 7 0 0 7 7 0 7 54 0 7 % L
% Met: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 7 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % N
% Pro: 14 0 0 0 0 0 67 0 7 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 7 0 7 0 0 7 7 34 0 0 0 7 % R
% Ser: 0 0 0 20 0 7 7 40 14 0 0 0 0 7 0 % S
% Thr: 7 14 0 54 0 0 0 0 40 0 20 7 0 0 7 % T
% Val: 0 27 0 0 0 7 0 0 0 0 0 0 20 0 0 % V
% Trp: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 0 0 0 0 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _