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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
28.48
Human Site:
S421
Identified Species:
44.76
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S421
S
Y
F
V
P
E
G
S
D
L
D
K
V
A
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
S173
I
E
A
Q
F
D
G
S
D
S
E
D
G
H
G
Dog
Lupus familis
XP_852722
879
98718
S419
S
Y
F
V
P
E
G
S
P
L
D
K
V
A
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S419
S
Y
F
V
P
E
G
S
S
L
D
K
V
A
A
Rat
Rattus norvegicus
Q5U2P0
1054
120741
S516
T
H
F
V
A
P
N
S
Y
I
D
V
E
A
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
T416
S
Y
F
V
L
E
E
T
A
L
D
R
V
A
S
Frog
Xenopus laevis
Q6GN11
1040
119148
T510
T
H
F
V
Q
H
N
T
Y
T
D
I
E
A
R
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
S511
T
H
F
V
R
E
G
S
L
T
D
L
E
A
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
N610
S
H
F
L
I
E
D
N
E
L
D
N
I
V
K
Honey Bee
Apis mellifera
XP_624734
786
91013
L378
L
S
P
G
Q
D
K
L
A
F
S
V
I
W
E
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
V396
L
C
S
L
N
P
G
V
D
R
L
S
F
S
T
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
D378
V
K
E
D
T
S
L
D
K
T
A
S
H
R
A
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
T442
S
Y
F
V
L
P
D
T
A
L
D
M
E
A
Q
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
T526
S
Y
F
V
L
P
E
T
A
L
D
T
E
A
R
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
T581
T
H
F
V
K
P
G
T
A
L
D
A
E
G
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
20
93.3
N.A.
93.3
33.3
N.A.
N.A.
60
26.6
46.6
N.A.
33.3
0
13.3
6.6
P-Site Similarity:
100
N.A.
33.3
93.3
N.A.
93.3
53.3
N.A.
N.A.
80
46.6
60
N.A.
66.6
13.3
26.6
6.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
46.6
N.A.
N.A.
46.6
40
N.A.
P-Site Similarity:
53.3
N.A.
N.A.
53.3
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
7
0
0
0
34
0
7
7
0
60
34
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
14
14
7
20
0
74
7
0
0
0
% D
% Glu:
0
7
7
0
0
40
14
0
7
0
7
0
40
0
7
% E
% Phe:
0
0
74
0
7
0
0
0
0
7
0
0
7
0
0
% F
% Gly:
0
0
0
7
0
0
47
0
0
0
0
0
7
7
7
% G
% His:
0
34
0
0
0
7
0
0
0
0
0
0
7
7
0
% H
% Ile:
7
0
0
0
7
0
0
0
0
7
0
7
14
0
0
% I
% Lys:
0
7
0
0
7
0
7
0
7
0
0
20
0
0
7
% K
% Leu:
14
0
0
14
20
0
7
7
7
54
7
7
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
0
0
7
0
14
7
0
0
0
7
0
0
0
% N
% Pro:
0
0
7
0
20
34
0
0
7
0
0
0
0
0
0
% P
% Gln:
0
0
0
7
14
0
0
0
0
0
0
0
0
0
7
% Q
% Arg:
0
0
0
0
7
0
0
0
0
7
0
7
0
7
27
% R
% Ser:
47
7
7
0
0
7
0
40
7
7
7
14
0
7
7
% S
% Thr:
27
0
0
0
7
0
0
34
0
20
0
7
0
0
7
% T
% Val:
7
0
0
67
0
0
0
7
0
0
0
14
27
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% W
% Tyr:
0
40
0
0
0
0
0
0
14
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _