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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
26.67
Human Site:
S454
Identified Species:
41.9
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S454
L
L
C
E
E
L
C
S
L
N
P
M
S
D
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
R202
V
C
V
S
E
K
G
R
E
D
G
D
A
P
V
Dog
Lupus familis
XP_852722
879
98718
S452
L
L
C
E
E
L
C
S
L
H
P
M
S
D
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S452
L
L
C
E
E
L
C
S
L
N
P
M
T
D
K
Rat
Rattus norvegicus
Q5U2P0
1054
120741
L550
L
S
A
D
L
C
S
L
L
G
G
V
D
R
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S449
L
L
C
E
E
L
C
S
L
N
P
M
R
D
R
Frog
Xenopus laevis
Q6GN11
1040
119148
L544
L
S
A
D
L
C
S
L
L
G
A
V
D
R
Y
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
L545
L
S
A
D
L
C
S
L
L
G
G
V
D
R
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
L644
L
C
M
R
C
S
L
L
P
G
Q
D
K
F
A
Honey Bee
Apis mellifera
XP_624734
786
91013
Q407
T
I
I
R
S
C
C
Q
M
S
Y
Y
H
A
Q
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
K428
S
V
I
R
S
R
V
K
L
A
Y
E
H
A
Q
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
S408
L
L
C
E
E
L
C
S
L
N
P
D
Q
E
R
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
S475
L
L
S
E
N
L
G
S
L
N
P
G
V
D
R
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
S559
L
L
S
E
N
V
G
S
L
S
P
G
A
D
R
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
S614
L
L
G
T
D
L
C
S
L
K
P
Y
V
D
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
6.6
93.3
N.A.
93.3
13.3
N.A.
N.A.
86.6
13.3
13.3
N.A.
6.6
6.6
6.6
73.3
P-Site Similarity:
100
N.A.
26.6
100
N.A.
100
26.6
N.A.
N.A.
93.3
26.6
26.6
N.A.
6.6
33.3
20
86.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
60
N.A.
N.A.
46.6
53.3
N.A.
P-Site Similarity:
66.6
N.A.
N.A.
73.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
20
0
0
0
0
0
0
7
7
0
14
14
7
% A
% Cys:
0
14
34
0
7
27
47
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
20
7
0
0
0
0
7
0
20
20
47
0
% D
% Glu:
0
0
0
47
40
0
0
0
7
0
0
7
0
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
0
0
7
0
0
0
20
0
0
27
20
14
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
14
0
0
% H
% Ile:
0
7
14
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
7
0
7
0
7
0
0
7
0
20
% K
% Leu:
80
54
0
0
20
47
7
27
80
0
0
0
0
0
0
% L
% Met:
0
0
7
0
0
0
0
0
7
0
0
27
0
0
0
% M
% Asn:
0
0
0
0
14
0
0
0
0
34
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
7
0
54
0
0
7
0
% P
% Gln:
0
0
0
0
0
0
0
7
0
0
7
0
7
0
14
% Q
% Arg:
0
0
0
20
0
7
0
7
0
0
0
0
7
20
34
% R
% Ser:
7
20
14
7
14
7
20
54
0
14
0
0
14
0
0
% S
% Thr:
7
0
0
7
0
0
0
0
0
0
0
0
7
0
0
% T
% Val:
7
7
7
0
0
7
7
0
0
0
0
20
14
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
14
14
0
0
20
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _