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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
15.76
Human Site:
S499
Identified Species:
24.76
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S499
L
S
Y
E
H
A
Q
S
M
I
E
S
P
T
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
A247
E
K
K
H
S
R
A
A
T
G
F
L
K
L
L
Dog
Lupus familis
XP_852722
879
98718
S497
L
S
Y
E
H
A
Q
S
M
I
E
S
P
T
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S497
L
S
Y
D
H
A
Q
S
M
I
E
N
P
T
E
Rat
Rattus norvegicus
Q5U2P0
1054
120741
E595
L
F
Y
E
A
A
Q
E
L
L
D
G
N
F
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S494
L
S
Y
D
H
A
Q
S
M
I
E
N
P
G
K
Frog
Xenopus laevis
Q6GN11
1040
119148
Q589
L
S
Y
E
V
A
Q
Q
L
L
D
G
D
L
E
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
S590
L
H
Y
E
L
A
Q
S
L
L
N
G
E
E
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
K689
F
A
Y
E
H
A
Q
K
I
I
D
N
P
N
E
Honey Bee
Apis mellifera
XP_624734
786
91013
I452
N
I
L
H
N
L
A
I
Q
M
R
K
K
R
F
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
A473
T
L
M
L
H
R
I
A
Q
V
L
R
Q
K
R
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
D453
L
S
Y
L
H
A
Q
D
M
I
E
N
W
E
E
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
G520
L
S
Y
E
H
A
Q
G
I
V
D
G
M
I
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
D604
L
S
Y
D
H
A
Q
D
I
I
D
G
K
S
D
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
L659
F
S
Y
E
Q
A
Q
L
R
I
D
D
K
T
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
100
N.A.
86.6
33.3
N.A.
N.A.
73.3
46.6
40
N.A.
53.3
0
6.6
66.6
P-Site Similarity:
100
N.A.
6.6
100
N.A.
100
53.3
N.A.
N.A.
93.3
66.6
53.3
N.A.
80
13.3
20
73.3
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
46.6
N.A.
N.A.
46.6
46.6
N.A.
P-Site Similarity:
73.3
N.A.
N.A.
80
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
7
80
14
14
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
20
0
0
0
14
0
0
40
7
7
0
14
% D
% Glu:
7
0
0
54
0
0
0
7
0
0
34
0
7
14
40
% E
% Phe:
14
7
0
0
0
0
0
0
0
0
7
0
0
7
7
% F
% Gly:
0
0
0
0
0
0
0
7
0
7
0
34
0
7
0
% G
% His:
0
7
0
14
60
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
7
7
20
54
0
0
0
7
0
% I
% Lys:
0
7
7
0
0
0
0
7
0
0
0
7
27
7
7
% K
% Leu:
67
7
7
14
7
7
0
7
20
20
7
7
0
14
7
% L
% Met:
0
0
7
0
0
0
0
0
34
7
0
0
7
0
0
% M
% Asn:
7
0
0
0
7
0
0
0
0
0
7
27
7
7
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
34
0
0
% P
% Gln:
0
0
0
0
7
0
80
7
14
0
0
0
7
0
7
% Q
% Arg:
0
0
0
0
0
14
0
0
7
0
7
7
0
7
7
% R
% Ser:
0
60
0
0
7
0
0
34
0
0
0
14
0
7
7
% S
% Thr:
7
0
0
0
0
0
0
0
7
0
0
0
0
27
0
% T
% Val:
0
0
0
0
7
0
0
0
0
14
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
0
0
80
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _