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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
4.24
Human Site:
S503
Identified Species:
6.67
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S503
H
A
Q
S
M
I
E
S
P
T
E
K
I
P
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
L251
S
R
A
A
T
G
F
L
K
L
L
A
D
K
N
Dog
Lupus familis
XP_852722
879
98718
S501
H
A
Q
S
M
I
E
S
P
T
E
K
I
P
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
N501
H
A
Q
S
M
I
E
N
P
T
E
K
I
P
E
Rat
Rattus norvegicus
Q5U2P0
1054
120741
G599
A
A
Q
E
L
L
D
G
N
F
S
I
V
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
N498
H
A
Q
S
M
I
E
N
P
G
K
V
F
S
P
Frog
Xenopus laevis
Q6GN11
1040
119148
G593
V
A
Q
Q
L
L
D
G
D
L
E
P
L
S
T
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
G594
L
A
Q
S
L
L
N
G
E
E
V
E
V
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
N693
H
A
Q
K
I
I
D
N
P
N
E
R
F
T
E
Honey Bee
Apis mellifera
XP_624734
786
91013
K456
N
L
A
I
Q
M
R
K
K
R
F
Q
N
G
A
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
R477
H
R
I
A
Q
V
L
R
Q
K
R
E
D
S
G
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
N457
H
A
Q
D
M
I
E
N
W
E
E
K
G
D
D
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
G524
H
A
Q
G
I
V
D
G
M
I
D
T
E
T
C
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
G608
H
A
Q
D
I
I
D
G
K
S
D
V
A
E
N
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
D663
Q
A
Q
L
R
I
D
D
K
T
Q
N
D
E
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
93.3
N.A.
86.6
13.3
N.A.
N.A.
53.3
20
26.6
N.A.
40
6.6
6.6
53.3
P-Site Similarity:
100
N.A.
6.6
93.3
N.A.
93.3
40
N.A.
N.A.
66.6
46.6
53.3
N.A.
66.6
26.6
26.6
60
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
20
N.A.
N.A.
26.6
26.6
N.A.
P-Site Similarity:
46.6
N.A.
N.A.
53.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
80
14
14
0
0
0
0
0
0
0
7
7
0
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
0
0
0
14
0
0
40
7
7
0
14
0
20
14
14
% D
% Glu:
0
0
0
7
0
0
34
0
7
14
40
14
7
14
27
% E
% Phe:
0
0
0
0
0
0
7
0
0
7
7
0
14
0
0
% F
% Gly:
0
0
0
7
0
7
0
34
0
7
0
0
7
7
7
% G
% His:
60
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
7
20
54
0
0
0
7
0
7
20
0
0
% I
% Lys:
0
0
0
7
0
0
0
7
27
7
7
27
0
7
0
% K
% Leu:
7
7
0
7
20
20
7
7
0
14
7
0
7
0
7
% L
% Met:
0
0
0
0
34
7
0
0
7
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
0
0
7
27
7
7
0
7
7
0
14
% N
% Pro:
0
0
0
0
0
0
0
0
34
0
0
7
0
27
7
% P
% Gln:
7
0
80
7
14
0
0
0
7
0
7
7
0
0
0
% Q
% Arg:
0
14
0
0
7
0
7
7
0
7
7
7
0
0
0
% R
% Ser:
7
0
0
34
0
0
0
14
0
7
7
0
0
20
0
% S
% Thr:
0
0
0
0
7
0
0
0
0
27
0
7
0
14
7
% T
% Val:
7
0
0
0
0
14
0
0
0
0
7
14
14
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _