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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
14.85
Human Site:
S517
Identified Species:
23.33
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S517
A
K
E
L
P
P
I
S
P
E
H
S
S
E
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Y265
N
S
E
L
F
R
K
Y
A
L
F
S
P
S
D
Dog
Lupus familis
XP_852722
879
98718
S515
E
E
E
L
P
P
I
S
P
E
H
T
S
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S515
E
E
E
L
P
P
I
S
P
E
H
S
V
E
E
Rat
Rattus norvegicus
Q5U2P0
1054
120741
L613
D
I
P
E
F
K
T
L
E
E
Q
N
R
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S512
P
E
E
L
P
P
I
S
P
Q
H
S
V
A
E
Frog
Xenopus laevis
Q6GN11
1040
119148
L607
T
E
K
E
L
H
P
L
K
Q
D
P
A
R
L
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
S608
E
L
N
P
L
K
G
S
Q
R
D
Q
K
M
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
L707
E
N
D
F
P
T
I
L
N
G
F
N
P
D
D
Honey Bee
Apis mellifera
XP_624734
786
91013
K470
A
L
Q
I
D
Q
P
K
L
Y
V
K
I
D
R
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
P491
G
A
L
R
I
E
L
P
R
L
K
F
A
L
D
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
T471
D
I
V
L
P
E
I
T
N
G
F
G
R
N
E
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
L538
C
N
T
F
G
D
S
L
P
Q
L
H
G
H
F
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
G622
N
G
W
P
A
L
H
G
S
F
K
W
C
D
V
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
L677
L
T
M
G
M
R
A
L
L
K
L
S
V
K
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
20
80
N.A.
80
6.6
N.A.
N.A.
66.6
0
6.6
N.A.
13.3
6.6
0
26.6
P-Site Similarity:
100
N.A.
26.6
93.3
N.A.
86.6
20
N.A.
N.A.
80
26.6
6.6
N.A.
40
26.6
20
33.3
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
0
0
7
0
7
0
7
0
0
0
14
7
7
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
14
0
7
0
7
7
0
0
0
0
14
0
0
20
20
% D
% Glu:
27
27
34
14
0
14
0
0
7
27
0
0
0
20
34
% E
% Phe:
0
0
0
14
14
0
0
0
0
7
20
7
0
0
7
% F
% Gly:
7
7
0
7
7
0
7
7
0
14
0
7
7
0
0
% G
% His:
0
0
0
0
0
7
7
0
0
0
27
7
0
7
0
% H
% Ile:
0
14
0
7
7
0
40
0
0
0
0
0
7
0
0
% I
% Lys:
0
7
7
0
0
14
7
7
7
7
14
7
7
7
0
% K
% Leu:
7
14
7
40
14
7
7
34
14
14
14
0
0
7
14
% L
% Met:
0
0
7
0
7
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
14
14
7
0
0
0
0
0
14
0
0
14
0
7
0
% N
% Pro:
7
0
7
14
40
27
14
7
34
0
0
7
14
0
0
% P
% Gln:
0
0
7
0
0
7
0
0
7
20
7
7
0
7
0
% Q
% Arg:
0
0
0
7
0
14
0
0
7
7
0
0
14
7
7
% R
% Ser:
0
7
0
0
0
0
7
34
7
0
0
34
14
7
7
% S
% Thr:
7
7
7
0
0
7
7
7
0
0
0
7
0
0
0
% T
% Val:
0
0
7
0
0
0
0
0
0
0
7
0
20
0
7
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _