KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
14.24
Human Site:
S521
Identified Species:
22.38
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S521
P
P
I
S
P
E
H
S
S
E
E
V
H
Q
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
S269
F
R
K
Y
A
L
F
S
P
S
D
H
R
V
P
Dog
Lupus familis
XP_852722
879
98718
T519
P
P
I
S
P
E
H
T
S
E
E
V
H
R
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S519
P
P
I
S
P
E
H
S
V
E
E
V
H
Q
A
Rat
Rattus norvegicus
Q5U2P0
1054
120741
N617
F
K
T
L
E
E
Q
N
R
Q
A
K
L
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S516
P
P
I
S
P
Q
H
S
V
A
E
I
Q
Q
A
Frog
Xenopus laevis
Q6GN11
1040
119148
P611
L
H
P
L
K
Q
D
P
A
R
L
Q
Q
L
L
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
Q612
L
K
G
S
Q
R
D
Q
K
M
S
E
L
L
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
N711
P
T
I
L
N
G
F
N
P
D
D
I
R
N
R
Honey Bee
Apis mellifera
XP_624734
786
91013
K474
D
Q
P
K
L
Y
V
K
I
D
R
I
T
G
L
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
F495
I
E
L
P
R
L
K
F
A
L
D
E
D
K
K
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
G475
P
E
I
T
N
G
F
G
R
N
E
V
A
Q
A
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
H542
G
D
S
L
P
Q
L
H
G
H
F
E
W
A
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
W626
A
L
H
G
S
F
K
W
C
D
V
T
R
S
V
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
S681
M
R
A
L
L
K
L
S
V
K
L
K
Q
K
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
6.6
86.6
N.A.
93.3
6.6
N.A.
N.A.
66.6
0
6.6
N.A.
13.3
0
0
40
P-Site Similarity:
100
N.A.
13.3
100
N.A.
93.3
26.6
N.A.
N.A.
80
13.3
6.6
N.A.
40
13.3
26.6
46.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
6.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
0
7
0
0
0
14
7
7
0
7
7
34
% A
% Cys:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
7
7
0
0
0
0
14
0
0
20
20
0
7
0
7
% D
% Glu:
0
14
0
0
7
27
0
0
0
20
34
20
0
7
7
% E
% Phe:
14
0
0
0
0
7
20
7
0
0
7
0
0
0
0
% F
% Gly:
7
0
7
7
0
14
0
7
7
0
0
0
0
7
0
% G
% His:
0
7
7
0
0
0
27
7
0
7
0
7
20
0
0
% H
% Ile:
7
0
40
0
0
0
0
0
7
0
0
20
0
0
0
% I
% Lys:
0
14
7
7
7
7
14
7
7
7
0
14
0
14
7
% K
% Leu:
14
7
7
34
14
14
14
0
0
7
14
0
14
14
14
% L
% Met:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
0
0
0
14
0
0
14
0
7
0
0
0
7
0
% N
% Pro:
40
27
14
7
34
0
0
7
14
0
0
0
0
0
7
% P
% Gln:
0
7
0
0
7
20
7
7
0
7
0
7
20
27
7
% Q
% Arg:
0
14
0
0
7
7
0
0
14
7
7
0
20
7
14
% R
% Ser:
0
0
7
34
7
0
0
34
14
7
7
0
0
7
0
% S
% Thr:
0
7
7
7
0
0
0
7
0
0
0
7
7
0
0
% T
% Val:
0
0
0
0
0
0
7
0
20
0
7
27
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
0
% W
% Tyr:
0
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _