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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
10.3
Human Site:
S60
Identified Species:
16.19
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S60
Y
M
S
K
E
D
V
S
E
G
L
K
R
G
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Dog
Lupus familis
XP_852722
879
98718
R63
D
V
S
E
G
L
K
R
G
T
L
I
Q
G
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S60
Y
M
S
K
E
D
V
S
E
G
L
K
R
G
T
Rat
Rattus norvegicus
Q5U2P0
1054
120741
Y69
D
W
K
V
V
Q
D
Y
L
E
V
L
E
F
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
R60
D
V
S
A
G
L
K
R
G
E
L
I
Q
G
P
Frog
Xenopus laevis
Q6GN11
1040
119148
R75
V
L
E
F
P
E
L
R
G
I
I
I
M
Q
T
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
N142
W
H
T
R
N
V
Y
N
A
A
V
W
Y
Y
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
L60
S
N
A
S
S
K
D
L
S
A
N
N
A
V
I
Honey Bee
Apis mellifera
XP_624734
786
91013
I60
E
E
R
K
E
K
E
I
K
S
Q
K
S
K
S
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
K62
G
V
L
R
I
N
P
K
N
Y
Q
E
C
F
L
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
P60
I
I
A
V
S
E
S
P
D
R
Q
G
S
S
T
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
N72
Y
W
S
T
E
T
V
N
E
A
L
E
K
G
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
T158
H
W
S
L
D
A
V
T
E
A
L
E
K
G
E
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
T206
R
L
N
R
E
A
A
T
K
E
V
E
S
N
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
20
N.A.
100
0
N.A.
N.A.
20
6.6
0
N.A.
0
20
0
6.6
P-Site Similarity:
100
N.A.
0
40
N.A.
100
6.6
N.A.
N.A.
33.3
33.3
33.3
N.A.
6.6
33.3
26.6
33.3
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
46.6
N.A.
N.A.
33.3
6.6
N.A.
P-Site Similarity:
66.6
N.A.
N.A.
66.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
14
7
0
14
7
0
7
27
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
20
0
0
0
7
14
14
0
7
0
0
0
0
0
7
% D
% Glu:
7
7
7
7
34
14
7
0
27
20
0
27
7
0
7
% E
% Phe:
0
0
0
7
0
0
0
0
0
0
0
0
0
14
0
% F
% Gly:
7
0
0
0
14
0
0
0
20
14
0
7
0
40
0
% G
% His:
7
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
7
0
0
7
0
0
7
0
7
7
20
0
0
14
% I
% Lys:
0
0
7
20
0
14
14
7
14
0
0
20
14
7
0
% K
% Leu:
0
14
7
7
0
14
7
7
7
0
40
7
0
0
7
% L
% Met:
0
14
0
0
0
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
0
7
7
0
7
7
0
14
7
0
7
7
0
7
7
% N
% Pro:
0
0
0
0
7
0
7
7
0
0
0
0
0
0
14
% P
% Gln:
0
0
0
0
0
7
0
0
0
0
20
0
14
7
0
% Q
% Arg:
7
0
7
20
0
0
0
20
0
7
0
0
14
0
0
% R
% Ser:
7
0
40
7
14
0
7
14
7
7
0
0
20
7
7
% S
% Thr:
0
0
7
7
0
7
0
14
0
7
0
0
0
0
27
% T
% Val:
7
20
0
14
7
7
27
0
0
0
20
0
0
7
7
% V
% Trp:
7
20
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
20
0
0
0
0
0
7
7
0
7
0
0
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _