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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
0.91
Human Site:
S619
Identified Species:
1.43
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S619
P
P
Q
T
R
M
L
S
D
L
V
E
F
C
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
L323
L
G
Q
L
A
K
S
L
G
Q
A
G
E
I
E
Dog
Lupus familis
XP_852722
879
98718
N617
P
P
Q
T
K
M
L
N
D
L
M
E
F
C
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
Q602
I
F
R
T
F
P
E
Q
A
L
L
R
R
H
P
Rat
Rattus norvegicus
Q5U2P0
1054
120741
A682
L
E
V
H
E
T
V
A
E
C
M
I
L
A
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
Q599
I
Y
R
S
F
P
E
Q
A
L
L
R
R
H
P
Frog
Xenopus laevis
Q6GN11
1040
119148
P704
L
L
R
L
H
P
P
P
R
Q
E
F
F
Q
E
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
A674
L
E
V
H
E
T
V
A
E
C
M
I
Y
A
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
A779
I
E
E
F
M
L
L
A
N
Q
A
V
A
R
F
Honey Bee
Apis mellifera
XP_624734
786
91013
P528
L
L
R
N
H
R
E
P
S
K
H
I
L
T
V
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
K555
P
P
K
E
K
M
I
K
D
V
A
E
Q
C
A
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
D531
Y
S
V
Y
Q
Q
K
D
S
N
R
L
V
E
E
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
C597
I
P
Y
D
S
S
L
C
E
R
K
D
S
N
F
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
K722
E
P
N
T
R
K
L
K
E
F
E
G
F
C
S
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
Y743
I
S
V
A
R
K
I
Y
D
A
F
P
Q
T
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
6.6
80
N.A.
13.3
0
N.A.
N.A.
6.6
6.6
0
N.A.
6.6
0
40
0
P-Site Similarity:
100
N.A.
13.3
100
N.A.
26.6
33.3
N.A.
N.A.
26.6
20
40
N.A.
33.3
6.6
66.6
13.3
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
13.3
N.A.
N.A.
40
13.3
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
46.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
7
0
0
20
14
7
20
0
7
14
14
% A
% Cys:
0
0
0
0
0
0
0
7
0
14
0
0
0
27
0
% C
% Asp:
0
0
0
7
0
0
0
7
27
0
0
7
0
0
14
% D
% Glu:
7
20
7
7
14
0
20
0
27
0
14
20
7
7
20
% E
% Phe:
0
7
0
7
14
0
0
0
0
7
7
7
27
0
14
% F
% Gly:
0
7
0
0
0
0
0
0
7
0
0
14
0
0
0
% G
% His:
0
0
0
14
14
0
0
0
0
0
7
0
0
14
0
% H
% Ile:
34
0
0
0
0
0
14
0
0
0
0
20
0
7
0
% I
% Lys:
0
0
7
0
14
20
7
14
0
7
7
0
0
0
0
% K
% Leu:
34
14
0
14
0
7
34
7
0
27
14
7
14
0
0
% L
% Met:
0
0
0
0
7
20
0
0
0
0
20
0
0
0
0
% M
% Asn:
0
0
7
7
0
0
0
7
7
7
0
0
0
7
14
% N
% Pro:
20
34
0
0
0
20
7
14
0
0
0
7
0
0
14
% P
% Gln:
0
0
20
0
7
7
0
14
0
20
0
0
14
7
0
% Q
% Arg:
0
0
27
0
20
7
0
0
7
7
7
14
14
7
0
% R
% Ser:
0
14
0
7
7
7
7
7
14
0
0
0
7
0
7
% S
% Thr:
0
0
0
27
0
14
0
0
0
0
0
0
0
14
0
% T
% Val:
0
0
27
0
0
0
14
0
0
7
7
7
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
7
7
7
0
0
0
7
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _