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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
10
Human Site:
S654
Identified Species:
15.71
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S654
T
F
G
D
D
K
Y
S
L
A
R
K
E
V
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Q357
E
V
L
E
C
L
P
Q
G
L
P
W
T
I
P
Dog
Lupus familis
XP_852722
879
98718
S652
T
F
G
D
D
K
Y
S
L
A
R
K
E
V
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
L642
A
G
A
L
N
K
S
L
T
K
T
F
G
D
D
Rat
Rattus norvegicus
Q5U2P0
1054
120741
S750
L
D
S
A
N
D
P
S
D
P
L
V
N
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S634
I
D
F
S
S
A
G
S
L
H
K
S
L
N
E
Frog
Xenopus laevis
Q6GN11
1040
119148
S742
L
D
Q
A
H
D
P
S
D
P
L
V
N
Q
L
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
R742
L
E
R
A
V
D
P
R
D
P
L
V
N
R
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
L818
L
R
E
K
L
L
A
L
G
F
E
L
D
Y
S
Honey Bee
Apis mellifera
XP_624734
786
91013
Y562
L
H
A
S
I
R
R
Y
E
Q
G
L
E
N
E
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
L589
K
Y
Q
G
K
S
R
L
D
M
C
I
R
Q
V
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
P565
R
A
F
L
R
R
H
P
P
P
K
E
K
M
M
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
P635
S
A
L
L
R
R
H
P
E
P
N
M
R
K
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
S758
T
G
N
L
K
D
D
S
V
F
V
D
I
L
N
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
S777
L
N
T
R
K
N
M
S
I
S
L
E
S
S
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
100
N.A.
6.6
13.3
N.A.
N.A.
13.3
13.3
6.6
N.A.
0
6.6
0
0
P-Site Similarity:
100
N.A.
13.3
100
N.A.
13.3
20
N.A.
N.A.
20
13.3
6.6
N.A.
6.6
13.3
13.3
46.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
6.6
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
14
14
20
0
7
7
0
0
14
0
0
0
0
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
0
20
0
14
14
27
7
0
27
0
0
7
7
7
7
% D
% Glu:
7
7
7
7
0
0
0
0
14
0
7
14
20
0
14
% E
% Phe:
0
14
14
0
0
0
0
0
0
14
0
7
0
0
0
% F
% Gly:
0
14
14
7
0
0
7
0
14
0
7
0
7
0
0
% G
% His:
0
7
0
0
7
0
14
0
0
7
0
0
0
0
0
% H
% Ile:
7
0
0
0
7
0
0
0
7
0
0
7
7
7
0
% I
% Lys:
7
0
0
7
20
20
0
0
0
7
14
14
7
14
7
% K
% Leu:
40
0
14
27
7
14
0
20
20
7
27
14
7
7
40
% L
% Met:
0
0
0
0
0
0
7
0
0
7
0
7
0
7
7
% M
% Asn:
0
7
7
0
14
7
0
0
0
0
7
0
20
14
7
% N
% Pro:
0
0
0
0
0
0
27
14
7
34
7
0
0
0
7
% P
% Gln:
0
0
14
0
0
0
0
7
0
7
0
0
0
14
0
% Q
% Arg:
7
7
7
7
14
20
14
7
0
0
14
0
14
7
0
% R
% Ser:
7
0
7
14
7
7
7
47
0
7
0
7
7
7
7
% S
% Thr:
20
0
7
0
0
0
0
0
7
0
7
0
7
0
0
% T
% Val:
0
7
0
0
7
0
0
0
7
0
7
20
0
14
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
7
0
0
0
0
14
7
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _