KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
7.58
Human Site:
S746
Identified Species:
11.9
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S746
C
N
D
R
R
M
A
S
K
R
V
Q
E
L
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
C449
P
M
L
P
R
L
L
C
E
E
L
C
S
L
N
Dog
Lupus familis
XP_852722
879
98718
S744
C
N
D
R
R
M
A
S
K
R
V
Q
E
L
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
A734
P
D
T
L
Q
K
Q
A
D
H
C
N
D
R
R
Rat
Rattus norvegicus
Q5U2P0
1054
120741
N842
E
L
C
R
H
I
N
N
R
N
R
A
A
Q
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
A726
P
I
K
M
E
K
E
A
I
Q
R
Q
A
E
H
Frog
Xenopus laevis
Q6GN11
1040
119148
A834
H
I
N
A
R
N
R
A
A
Q
Q
C
Q
K
Q
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
N834
E
L
A
Q
H
I
N
N
K
N
R
A
A
Q
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
K910
R
L
L
A
A
A
L
K
Y
C
T
P
P
K
R
Honey Bee
Apis mellifera
XP_624734
786
91013
K654
M
P
K
E
W
S
K
K
L
C
K
S
I
A
A
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
S681
C
N
D
T
K
L
A
S
K
E
A
S
D
E
S
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
I657
Y
T
H
F
T
S
P
I
R
R
Y
P
D
I
L
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
L727
Y
T
H
F
T
S
P
L
R
R
Y
P
D
I
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
N850
C
F
T
G
I
H
F
N
K
D
A
A
E
S
I
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
L869
I
G
Y
E
P
L
S
L
T
H
R
D
K
N
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
13.3
100
N.A.
0
6.6
N.A.
N.A.
6.6
6.6
6.6
N.A.
0
0
46.6
6.6
P-Site Similarity:
100
N.A.
40
100
N.A.
26.6
26.6
N.A.
N.A.
20
33.3
26.6
N.A.
0
6.6
66.6
26.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
6.6
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
14
7
7
20
20
7
0
14
20
20
7
7
% A
% Cys:
27
0
7
0
0
0
0
7
0
14
7
14
0
0
0
% C
% Asp:
0
7
20
0
0
0
0
0
7
7
0
7
27
0
0
% D
% Glu:
14
0
0
14
7
0
7
0
7
14
0
0
20
14
0
% E
% Phe:
0
7
0
14
0
0
7
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
7
0
14
0
14
7
0
0
0
14
0
0
0
0
14
% H
% Ile:
7
14
0
0
7
14
0
7
7
0
0
0
7
14
7
% I
% Lys:
0
0
14
0
7
14
7
14
34
0
7
0
7
14
7
% K
% Leu:
0
20
14
7
0
20
14
14
7
0
7
0
0
20
7
% L
% Met:
7
7
0
7
0
14
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
20
7
0
0
7
14
20
0
14
0
7
0
7
7
% N
% Pro:
20
7
0
7
7
0
14
0
0
0
0
20
7
0
0
% P
% Gln:
0
0
0
7
7
0
7
0
0
14
7
20
7
14
7
% Q
% Arg:
7
0
0
20
27
0
7
0
20
27
27
0
0
7
20
% R
% Ser:
0
0
0
0
0
20
7
20
0
0
0
14
7
7
20
% S
% Thr:
0
14
14
7
14
0
0
0
7
0
7
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
14
0
0
0
7
% V
% Trp:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
14
0
7
0
0
0
0
0
7
0
14
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _