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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
14.85
Human Site:
S87
Identified Species:
23.33
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S87
F
H
E
A
F
I
P
S
P
D
G
D
R
D
I
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Dog
Lupus familis
XP_852722
879
98718
S85
F
H
E
A
F
I
P
S
P
D
G
D
R
D
I
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S87
F
H
E
A
F
I
P
S
P
D
G
D
R
D
I
Rat
Rattus norvegicus
Q5U2P0
1054
120741
A118
R
H
D
C
V
L
F
A
N
E
F
Q
Q
H
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S82
Y
H
E
A
F
I
P
S
P
D
G
T
R
D
I
Frog
Xenopus laevis
Q6GN11
1040
119148
R125
Q
N
H
A
Y
L
P
R
E
M
G
E
S
A
L
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
D192
Y
L
L
G
F
W
P
D
L
Q
A
A
H
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
Y122
Y
H
V
A
F
A
S
Y
Q
A
T
M
Q
I
P
Honey Bee
Apis mellifera
XP_624734
786
91013
I83
R
H
I
S
E
K
E
I
D
K
L
L
K
N
Q
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
G84
H
P
D
V
L
V
L
G
Q
D
R
N
R
A
M
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
G83
L
G
G
R
Y
F
F
G
S
Q
G
D
F
D
T
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
A117
G
I
A
A
Q
N
R
A
M
D
G
D
V
V
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
I185
R
N
E
A
Y
C
K
I
D
G
V
P
T
D
I
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
M238
I
R
D
S
I
P
Q
M
D
S
F
D
K
D
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
100
N.A.
100
6.6
N.A.
N.A.
86.6
20
20
N.A.
20
6.6
13.3
20
P-Site Similarity:
100
N.A.
0
100
N.A.
100
40
N.A.
N.A.
93.3
53.3
33.3
N.A.
33.3
26.6
40
26.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
26.6
N.A.
N.A.
26.6
13.3
N.A.
P-Site Similarity:
40
N.A.
N.A.
40
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
54
0
7
0
14
0
7
7
7
0
14
0
% A
% Cys:
0
0
0
7
0
7
0
0
0
0
0
0
0
0
7
% C
% Asp:
0
0
20
0
0
0
0
7
20
40
0
40
0
54
0
% D
% Glu:
0
0
34
0
7
0
7
0
7
7
0
7
0
0
0
% E
% Phe:
20
0
0
0
40
7
14
0
0
0
14
0
7
0
0
% F
% Gly:
7
7
7
7
0
0
0
14
0
7
47
0
0
0
0
% G
% His:
7
47
7
0
0
0
0
0
0
0
0
0
7
7
0
% H
% Ile:
7
7
7
0
7
27
0
14
0
0
0
0
0
7
34
% I
% Lys:
0
0
0
0
0
7
7
0
0
7
0
0
14
0
0
% K
% Leu:
7
7
7
0
7
14
7
0
7
0
7
7
0
0
20
% L
% Met:
0
0
0
0
0
0
0
7
7
7
0
7
0
0
7
% M
% Asn:
0
14
0
0
0
7
0
0
7
0
0
7
0
7
0
% N
% Pro:
0
7
0
0
0
7
40
0
27
0
0
7
0
0
7
% P
% Gln:
7
0
0
0
7
0
7
0
14
14
0
7
14
0
7
% Q
% Arg:
20
7
0
7
0
0
7
7
0
0
7
0
34
0
0
% R
% Ser:
0
0
0
14
0
0
7
27
7
7
0
0
7
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
7
7
7
0
7
% T
% Val:
0
0
7
7
7
7
0
0
0
0
7
0
7
7
7
% V
% Trp:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% W
% Tyr:
20
0
0
0
20
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _