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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
6.97
Human Site:
S875
Identified Species:
10.95
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S875
P
E
K
E
E
E
E
S
D
G
E
P
E
D
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
H571
T
G
L
P
Q
G
C
H
I
Y
E
Y
R
D
S
Dog
Lupus familis
XP_852722
879
98718
E870
L
L
G
L
Q
H
H
E
E
R
A
D
S
G
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
K856
L
K
Y
S
A
I
L
K
R
P
G
L
E
K
A
Rat
Rattus norvegicus
Q5U2P0
1054
120741
T1028
E
H
Q
E
Y
R
Q
T
K
G
R
S
L
Y
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S849
D
G
V
P
L
K
Y
S
A
L
L
K
R
P
S
Frog
Xenopus laevis
Q6GN11
1040
119148
Q1012
L
K
P
V
E
R
Y
Q
E
Y
R
Q
T
Q
G
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
T1046
D
L
S
I
C
Q
I
T
N
S
E
E
Q
T
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
T1035
I
I
W
D
Q
K
L
T
G
F
L
K
M
E
E
Honey Bee
Apis mellifera
XP_624734
786
91013
L777
S
F
Q
L
I
G
N
L
L
P
P
N
Q
E
I
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
M808
L
K
S
T
L
K
D
M
K
E
T
G
S
T
I
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
F790
V
T
Q
V
I
K
M
F
S
Q
V
T
V
E
L
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
R851
R
V
L
G
L
G
P
R
F
M
S
I
Y
I
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
I1023
P
A
V
F
P
L
T
I
Q
L
F
S
T
I
P
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
S992
S
V
M
D
P
I
T
S
K
R
K
A
E
L
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
20
0
N.A.
6.6
13.3
N.A.
N.A.
13.3
6.6
6.6
N.A.
0
0
0
0
P-Site Similarity:
100
N.A.
26.6
13.3
N.A.
20
40
N.A.
N.A.
20
20
33.3
N.A.
33.3
20
20
20
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
6.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
7
0
0
0
7
0
7
7
0
0
7
% A
% Cys:
0
0
0
0
7
0
7
0
0
0
0
0
0
0
7
% C
% Asp:
14
0
0
14
0
0
7
0
7
0
0
7
0
14
0
% D
% Glu:
7
7
0
14
14
7
7
7
14
7
20
7
20
20
7
% E
% Phe:
0
7
0
7
0
0
0
7
7
7
7
0
0
0
0
% F
% Gly:
0
14
7
7
0
20
0
0
7
14
7
7
0
7
7
% G
% His:
0
7
0
0
0
7
7
7
0
0
0
0
0
0
0
% H
% Ile:
7
7
0
7
14
14
7
7
7
0
0
7
0
14
14
% I
% Lys:
0
20
7
0
0
27
0
7
20
0
7
14
0
7
0
% K
% Leu:
27
14
14
14
20
7
14
7
7
14
14
7
7
7
14
% L
% Met:
0
0
7
0
0
0
7
7
0
7
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
7
0
7
0
0
7
0
0
7
% N
% Pro:
14
0
7
14
14
0
7
0
0
14
7
7
0
7
7
% P
% Gln:
0
0
20
0
20
7
7
7
7
7
0
7
14
7
7
% Q
% Arg:
7
0
0
0
0
14
0
7
7
14
14
0
14
0
0
% R
% Ser:
14
0
14
7
0
0
0
20
7
7
7
14
14
0
20
% S
% Thr:
7
7
0
7
0
0
14
20
0
0
7
7
14
14
7
% T
% Val:
7
14
14
14
0
0
0
0
0
0
7
0
7
0
0
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
7
0
14
0
0
14
0
7
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _