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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
5.15
Human Site:
T214
Identified Species:
8.1
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
T214
A
P
V
T
K
D
E
T
T
C
I
S
Q
D
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Dog
Lupus familis
XP_852722
879
98718
S212
A
L
V
T
K
E
E
S
T
S
T
S
Q
D
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
N212
T
P
V
M
K
D
E
N
T
P
I
P
Q
D
T
Rat
Rattus norvegicus
Q5U2P0
1054
120741
S271
Q
G
A
S
S
K
D
S
G
L
V
S
D
I
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
V209
G
T
T
K
Q
E
E
V
P
K
A
T
P
D
P
Frog
Xenopus laevis
Q6GN11
1040
119148
G302
L
P
K
S
E
W
K
G
R
T
G
A
L
C
E
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
G300
L
P
R
N
E
W
K
G
R
T
M
A
L
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
N321
E
I
R
V
N
R
K
N
N
R
Q
A
F
I
I
Honey Bee
Apis mellifera
XP_624734
786
91013
F185
C
F
K
Q
R
G
A
F
T
F
F
Y
P
R
D
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
M187
A
A
G
K
L
Q
L
M
P
N
S
A
N
P
N
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
P184
G
G
T
L
G
N
D
P
R
M
A
P
K
T
A
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
G218
D
E
V
S
N
S
V
G
R
I
C
A
M
L
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
H316
G
I
L
S
S
F
P
H
K
R
P
T
G
Q
V
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
R370
T
V
I
S
D
K
Q
R
R
L
L
A
K
D
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
66.6
N.A.
66.6
6.6
N.A.
N.A.
13.3
6.6
6.6
N.A.
0
6.6
6.6
0
P-Site Similarity:
100
N.A.
0
80
N.A.
66.6
33.3
N.A.
N.A.
33.3
33.3
33.3
N.A.
13.3
13.3
13.3
20
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
20
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
7
7
0
0
0
7
0
0
0
14
40
0
0
14
% A
% Cys:
7
0
0
0
0
0
0
0
0
7
7
0
0
7
0
% C
% Asp:
7
0
0
0
7
14
14
0
0
0
0
0
7
34
7
% D
% Glu:
7
7
0
0
14
14
27
0
0
0
0
0
0
0
14
% E
% Phe:
0
7
0
0
0
7
0
7
0
7
7
0
7
0
0
% F
% Gly:
20
14
7
0
7
7
0
20
7
0
7
0
7
0
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
14
7
0
0
0
0
0
0
7
14
0
0
14
7
% I
% Lys:
0
0
14
14
20
14
20
0
7
7
0
0
14
0
0
% K
% Leu:
14
7
7
7
7
0
7
0
0
14
7
0
14
7
7
% L
% Met:
0
0
0
7
0
0
0
7
0
7
7
0
7
0
0
% M
% Asn:
0
0
0
7
14
7
0
14
7
7
0
0
7
0
7
% N
% Pro:
0
27
0
0
0
0
7
7
14
7
7
14
14
7
7
% P
% Gln:
7
0
0
7
7
7
7
0
0
0
7
0
20
7
0
% Q
% Arg:
0
0
14
0
7
7
0
7
34
14
0
0
0
7
0
% R
% Ser:
0
0
0
34
14
7
0
14
0
7
7
20
0
0
7
% S
% Thr:
14
7
14
14
0
0
0
7
27
14
7
14
0
14
20
% T
% Val:
0
7
27
7
0
0
7
7
0
0
7
0
0
0
7
% V
% Trp:
0
0
0
0
0
14
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _