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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
13.33
Human Site:
T248
Identified Species:
20.95
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
T248
K
K
H
S
R
A
A
T
G
F
L
K
L
L
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
G14
R
M
N
L
R
P
L
G
T
P
R
G
V
S
T
Dog
Lupus familis
XP_852722
879
98718
T246
K
K
H
S
R
A
A
T
G
F
L
K
L
L
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
T246
K
K
H
S
R
A
A
T
G
I
L
K
L
L
A
Rat
Rattus norvegicus
Q5U2P0
1054
120741
K305
L
L
P
K
S
E
W
K
G
R
T
A
A
L
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
T243
K
K
H
S
R
A
A
T
G
F
I
K
L
L
A
Frog
Xenopus laevis
Q6GN11
1040
119148
N336
V
V
G
I
M
Q
R
N
W
R
D
Y
V
V
T
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
R334
R
V
V
E
I
L
Q
R
N
W
R
D
Y
V
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
D355
R
R
Y
A
F
D
G
D
K
V
R
A
F
V
L
Honey Bee
Apis mellifera
XP_624734
786
91013
L219
P
S
S
Y
E
D
T
L
Y
L
V
V
I
T
D
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
R221
V
D
K
E
F
F
S
R
P
K
D
F
E
R
F
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
P218
L
P
S
N
P
R
A
P
D
V
M
F
A
P
T
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
F252
R
R
D
V
I
V
G
F
L
N
V
K
Q
W
F
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
E350
K
G
W
I
H
Y
K
E
S
D
P
K
R
C
K
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
V404
R
R
S
W
R
Q
Y
V
G
Q
L
A
P
S
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
6.6
100
N.A.
93.3
13.3
N.A.
N.A.
93.3
0
0
N.A.
0
0
0
6.6
P-Site Similarity:
100
N.A.
26.6
100
N.A.
93.3
13.3
N.A.
N.A.
100
13.3
20
N.A.
33.3
13.3
6.6
20
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
6.6
N.A.
N.A.
13.3
20
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
13.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
27
34
0
0
0
0
20
14
0
27
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
7
% C
% Asp:
0
7
7
0
0
14
0
7
7
7
14
7
0
0
7
% D
% Glu:
0
0
0
14
7
7
0
7
0
0
0
0
7
0
0
% E
% Phe:
0
0
0
0
14
7
0
7
0
20
0
14
7
0
14
% F
% Gly:
0
7
7
0
0
0
14
7
40
0
0
7
0
0
0
% G
% His:
0
0
27
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
14
14
0
0
0
0
7
7
0
7
0
0
% I
% Lys:
34
27
7
7
0
0
7
7
7
7
0
40
0
0
7
% K
% Leu:
14
7
0
7
0
7
7
7
7
7
27
0
27
34
7
% L
% Met:
0
7
0
0
7
0
0
0
0
0
7
0
0
0
0
% M
% Asn:
0
0
7
7
0
0
0
7
7
7
0
0
0
0
0
% N
% Pro:
7
7
7
0
7
7
0
7
7
7
7
0
7
7
0
% P
% Gln:
0
0
0
0
0
14
7
0
0
7
0
0
7
0
0
% Q
% Arg:
34
20
0
0
40
7
7
14
0
14
20
0
7
7
0
% R
% Ser:
0
7
20
27
7
0
7
0
7
0
0
0
0
14
7
% S
% Thr:
0
0
0
0
0
0
7
27
7
0
7
0
0
7
20
% T
% Val:
14
14
7
7
0
7
0
7
0
14
14
7
14
20
7
% V
% Trp:
0
0
7
7
0
0
7
0
7
7
0
0
0
7
0
% W
% Tyr:
0
0
7
7
0
7
7
0
7
0
0
7
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _