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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
32.12
Human Site:
T381
Identified Species:
50.48
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
T381
L
R
K
D
C
I
F
T
I
D
P
S
T
A
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Y137
D
K
E
T
E
A
A
Y
E
S
D
I
P
E
E
Dog
Lupus familis
XP_852722
879
98718
T379
L
R
K
D
C
I
F
T
I
D
P
S
T
A
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
T379
L
R
K
D
C
I
F
T
I
D
P
S
T
A
R
Rat
Rattus norvegicus
Q5U2P0
1054
120741
S476
R
S
T
H
L
V
F
S
I
D
P
K
G
C
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
T376
L
R
K
E
C
I
F
T
I
D
P
S
T
A
K
Frog
Xenopus laevis
Q6GN11
1040
119148
S470
R
E
T
H
L
V
F
S
I
D
P
K
G
C
E
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
S470
R
D
S
H
L
V
F
S
I
D
P
K
G
C
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
T570
L
R
K
M
C
I
F
T
I
D
P
M
T
A
R
Honey Bee
Apis mellifera
XP_624734
786
91013
I342
E
F
L
S
P
L
D
I
Q
V
S
K
R
A
T
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
L360
F
L
K
E
G
T
E
L
D
K
W
A
S
E
R
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
R342
T
I
D
P
T
T
A
R
D
L
D
D
A
L
H
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
T402
I
R
N
L
C
I
F
T
I
D
P
S
S
A
T
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
T486
L
R
D
L
C
V
L
T
I
D
P
S
T
A
T
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
T529
V
S
K
D
P
L
L
T
K
R
K
D
L
R
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
100
N.A.
100
26.6
N.A.
N.A.
86.6
26.6
26.6
N.A.
86.6
6.6
13.3
0
P-Site Similarity:
100
N.A.
13.3
100
N.A.
100
40
N.A.
N.A.
100
40
40
N.A.
86.6
13.3
33.3
0
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
66.6
N.A.
N.A.
66.6
20
N.A.
P-Site Similarity:
80
N.A.
N.A.
73.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
14
0
0
0
0
7
7
54
0
% A
% Cys:
0
0
0
0
47
0
0
0
0
0
0
0
0
20
0
% C
% Asp:
7
7
14
27
0
0
7
0
14
67
14
14
0
0
7
% D
% Glu:
7
7
7
14
7
0
7
0
7
0
0
0
0
14
27
% E
% Phe:
7
7
0
0
0
0
60
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
0
0
0
0
0
0
20
0
0
% G
% His:
0
0
0
20
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
7
7
0
0
0
40
0
7
67
0
0
7
0
0
0
% I
% Lys:
0
7
47
0
0
0
0
0
7
7
7
27
0
0
7
% K
% Leu:
40
7
7
14
20
14
14
7
0
7
0
0
7
7
0
% L
% Met:
0
0
0
7
0
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
7
14
0
0
0
0
0
67
0
7
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% Q
% Arg:
20
47
0
0
0
0
0
7
0
7
0
0
7
7
34
% R
% Ser:
0
14
7
7
0
0
0
20
0
7
7
40
14
0
0
% S
% Thr:
7
0
14
7
7
14
0
54
0
0
0
0
40
0
20
% T
% Val:
7
0
0
0
0
27
0
0
0
7
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _