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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
23.33
Human Site:
T490
Identified Species:
36.67
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
T490
R
T
I
I
R
S
C
T
K
L
S
Y
E
H
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
I238
R
S
A
K
V
V
Y
I
L
E
K
K
H
S
R
Dog
Lupus familis
XP_852722
879
98718
T488
R
T
I
I
R
S
C
T
K
L
S
Y
E
H
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
T488
R
T
I
I
R
S
C
T
K
L
S
Y
D
H
A
Rat
Rattus norvegicus
Q5U2P0
1054
120741
Y586
R
T
I
I
R
S
A
Y
K
L
F
Y
E
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
A485
R
T
V
I
C
S
C
A
K
L
S
Y
D
H
A
Frog
Xenopus laevis
Q6GN11
1040
119148
Y580
R
T
I
I
R
S
S
Y
K
L
S
Y
E
V
A
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
Y581
R
T
L
I
R
S
S
Y
Q
L
H
Y
E
L
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
S680
R
T
V
I
N
S
C
S
Q
F
A
Y
E
H
A
Honey Bee
Apis mellifera
XP_624734
786
91013
K443
N
F
N
D
L
S
I
K
V
N
I
L
H
N
L
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
E464
N
T
P
F
E
I
K
E
K
T
L
M
L
H
R
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
V444
R
S
V
I
R
S
C
V
K
L
S
Y
L
H
A
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
C511
R
T
V
I
Q
S
C
C
K
L
S
Y
E
H
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
C595
R
T
I
I
R
S
C
C
K
L
S
Y
D
H
A
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
E650
K
S
V
I
R
S
R
E
A
F
S
Y
E
Q
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
6.6
100
N.A.
93.3
73.3
N.A.
N.A.
73.3
80
60
N.A.
60
6.6
20
73.3
P-Site Similarity:
100
N.A.
13.3
100
N.A.
100
73.3
N.A.
N.A.
86.6
80
73.3
N.A.
86.6
13.3
20
86.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
80
N.A.
N.A.
86.6
46.6
N.A.
P-Site Similarity:
93.3
N.A.
N.A.
93.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
7
7
7
0
7
0
0
7
80
% A
% Cys:
0
0
0
0
7
0
54
14
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
0
0
0
0
0
0
0
20
0
0
% D
% Glu:
0
0
0
0
7
0
0
14
0
7
0
0
54
0
0
% E
% Phe:
0
7
0
7
0
0
0
0
0
14
7
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
14
60
0
% H
% Ile:
0
0
40
80
0
7
7
7
0
0
7
0
0
0
0
% I
% Lys:
7
0
0
7
0
0
7
7
67
0
7
7
0
0
0
% K
% Leu:
0
0
7
0
7
0
0
0
7
67
7
7
14
7
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
14
0
7
0
7
0
0
0
0
7
0
0
0
7
0
% N
% Pro:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
7
0
0
0
14
0
0
0
0
7
0
% Q
% Arg:
80
0
0
0
60
0
7
0
0
0
0
0
0
0
14
% R
% Ser:
0
20
0
0
0
87
14
7
0
0
60
0
0
7
0
% S
% Thr:
0
74
0
0
0
0
0
20
0
7
0
0
0
0
0
% T
% Val:
0
0
34
0
7
7
0
7
7
0
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
20
0
0
0
80
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _