KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
14.85
Human Site:
T559
Identified Species:
23.33
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
T559
D
Q
L
K
L
A
F
T
L
D
H
E
T
G
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
C285
I
Y
V
P
L
K
D
C
P
Q
D
F
V
A
R
Dog
Lupus familis
XP_852722
879
98718
T557
D
Q
L
K
L
A
F
T
L
D
H
E
T
G
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
T557
D
Q
L
K
L
A
F
T
L
D
H
E
T
G
L
Rat
Rattus norvegicus
Q5U2P0
1054
120741
H638
K
L
T
D
I
A
R
H
I
R
A
K
R
D
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
T554
D
Q
L
K
L
S
F
T
L
D
Q
E
S
G
M
Frog
Xenopus laevis
Q6GN11
1040
119148
A640
M
R
R
N
M
S
G
A
L
E
L
E
G
V
E
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
H630
T
L
T
R
V
A
R
H
L
R
A
Q
R
D
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
T740
R
L
D
N
G
A
L
T
I
N
N
A
K
L
R
Honey Bee
Apis mellifera
XP_624734
786
91013
Q490
I
S
Y
N
I
E
E
Q
K
D
S
N
R
L
I
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
I511
Q
G
V
S
I
Y
E
I
K
D
S
N
K
L
V
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
N492
N
M
Q
K
I
A
S
N
L
R
K
K
R
F
D
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
E559
G
S
V
V
C
L
H
E
I
S
K
T
L
R
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
F662
L
E
N
S
K
P
V
F
L
F
D
E
H
G
V
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
H704
A
S
P
E
V
K
V
H
M
D
S
E
T
S
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
6.6
100
N.A.
100
6.6
N.A.
N.A.
73.3
13.3
13.3
N.A.
13.3
6.6
6.6
20
P-Site Similarity:
100
N.A.
13.3
100
N.A.
100
26.6
N.A.
N.A.
93.3
40
33.3
N.A.
33.3
20
26.6
40
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
0
N.A.
N.A.
20
20
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
33.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
47
0
7
0
0
14
7
0
7
0
% A
% Cys:
0
0
0
0
7
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
27
0
7
7
0
0
7
0
0
47
14
0
0
14
14
% D
% Glu:
0
7
0
7
0
7
14
7
0
7
0
47
0
0
14
% E
% Phe:
0
0
0
0
0
0
27
7
0
7
0
7
0
7
0
% F
% Gly:
7
7
0
0
7
0
7
0
0
0
0
0
7
34
0
% G
% His:
0
0
0
0
0
0
7
20
0
0
20
0
7
0
0
% H
% Ile:
14
0
0
0
27
0
0
7
20
0
0
0
0
0
7
% I
% Lys:
7
0
0
34
7
14
0
0
14
0
14
14
14
0
7
% K
% Leu:
7
20
27
0
34
7
7
0
54
0
7
0
7
20
20
% L
% Met:
7
7
0
0
7
0
0
0
7
0
0
0
0
0
7
% M
% Asn:
7
0
7
20
0
0
0
7
0
7
7
14
0
0
0
% N
% Pro:
0
0
7
7
0
7
0
0
7
0
0
0
0
0
0
% P
% Gln:
7
27
7
0
0
0
0
7
0
7
7
7
0
0
0
% Q
% Arg:
7
7
7
7
0
0
14
0
0
20
0
0
27
7
20
% R
% Ser:
0
20
0
14
0
14
7
0
0
7
20
0
7
7
0
% S
% Thr:
7
0
14
0
0
0
0
34
0
0
0
7
27
0
0
% T
% Val:
0
0
20
7
14
0
14
0
0
0
0
0
7
7
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
7
0
0
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _