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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
7.58
Human Site:
T647
Identified Species:
11.9
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
T647
L
N
K
S
L
T
Q
T
F
G
D
D
K
Y
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
E350
D
F
S
D
F
S
S
E
V
L
E
C
L
P
Q
Dog
Lupus familis
XP_852722
879
98718
T645
L
N
K
S
L
T
E
T
F
G
D
D
K
Y
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
A635
L
P
M
D
V
S
S
A
G
A
L
N
K
S
L
Rat
Rattus norvegicus
Q5U2P0
1054
120741
L743
N
K
T
L
A
D
S
L
D
S
A
N
D
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
I627
C
H
Q
V
G
L
E
I
D
F
S
S
A
G
S
Frog
Xenopus laevis
Q6GN11
1040
119148
L735
N
K
A
L
A
D
S
L
D
Q
A
H
D
P
S
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
L735
N
R
A
L
A
D
S
L
E
R
A
V
D
P
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
L811
L
I
K
S
L
K
A
L
R
E
K
L
L
A
L
Honey Bee
Apis mellifera
XP_624734
786
91013
L555
D
I
K
S
S
A
S
L
H
A
S
I
R
R
Y
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
K582
L
L
S
T
S
L
R
K
Y
Q
G
K
S
R
L
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
R558
I
F
K
A
E
P
Q
R
A
F
L
R
R
H
P
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
S628
I
S
R
A
F
P
D
S
A
L
L
R
R
H
P
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
T751
Q
D
S
L
E
K
I
T
G
N
L
K
D
D
S
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
L770
F
E
I
L
N
E
M
L
N
T
R
K
N
M
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
93.3
N.A.
13.3
6.6
N.A.
N.A.
6.6
6.6
0
N.A.
26.6
13.3
6.6
13.3
P-Site Similarity:
100
N.A.
13.3
100
N.A.
33.3
13.3
N.A.
N.A.
26.6
6.6
0
N.A.
26.6
20
26.6
40
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
0
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
46.6
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
14
14
20
7
7
7
14
14
20
0
7
7
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% C
% Asp:
14
7
0
14
0
20
7
0
20
0
14
14
27
7
0
% D
% Glu:
0
7
0
0
14
7
14
7
7
7
7
0
0
0
0
% E
% Phe:
7
14
0
0
14
0
0
0
14
14
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
0
0
14
14
7
0
0
7
0
% G
% His:
0
7
0
0
0
0
0
0
7
0
0
7
0
14
0
% H
% Ile:
14
14
7
0
0
0
7
7
0
0
0
7
0
0
0
% I
% Lys:
0
14
34
0
0
14
0
7
0
0
7
20
20
0
0
% K
% Leu:
34
7
0
34
20
14
0
40
0
14
27
7
14
0
20
% L
% Met:
0
0
7
0
0
0
7
0
0
0
0
0
0
7
0
% M
% Asn:
20
14
0
0
7
0
0
0
7
7
0
14
7
0
0
% N
% Pro:
0
7
0
0
0
14
0
0
0
0
0
0
0
27
14
% P
% Gln:
7
0
7
0
0
0
14
0
0
14
0
0
0
0
7
% Q
% Arg:
0
7
7
0
0
0
7
7
7
7
7
14
20
14
7
% R
% Ser:
0
7
20
27
14
14
40
7
0
7
14
7
7
7
47
% S
% Thr:
0
0
7
7
0
14
0
20
0
7
0
0
0
0
0
% T
% Val:
0
0
0
7
7
0
0
0
7
0
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
7
0
0
0
0
14
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _