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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
7.88
Human Site:
T67
Identified Species:
12.38
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
T67
S
E
G
L
K
R
G
T
L
I
Q
G
V
L
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Dog
Lupus familis
XP_852722
879
98718
V70
R
G
T
L
I
Q
G
V
L
R
I
N
P
K
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
T67
S
E
G
L
K
R
G
T
L
I
Q
G
V
L
R
Rat
Rattus norvegicus
Q5U2P0
1054
120741
P76
Y
L
E
V
L
E
F
P
E
L
K
G
I
I
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
P67
R
G
E
L
I
Q
G
P
L
R
I
N
P
K
K
Frog
Xenopus laevis
Q6GN11
1040
119148
T82
R
G
I
I
I
M
Q
T
A
C
Q
A
V
Q
H
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
N149
N
A
A
V
W
Y
Y
N
H
L
A
G
L
Q
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
I67
L
S
A
N
N
A
V
I
P
L
Q
P
L
M
R
Honey Bee
Apis mellifera
XP_624734
786
91013
S67
I
K
S
Q
K
S
K
S
S
K
Q
K
E
T
F
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
L69
K
N
Y
Q
E
C
F
L
D
H
P
K
G
T
N
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
T67
P
D
R
Q
G
S
S
T
P
G
S
S
T
P
K
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
D79
N
E
A
L
E
K
G
D
V
F
K
V
L
F
R
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
E165
T
E
A
L
E
K
G
E
A
F
K
A
L
F
R
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
I213
T
K
E
V
E
S
N
I
I
T
K
S
L
V
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
20
N.A.
100
6.6
N.A.
N.A.
20
20
6.6
N.A.
13.3
13.3
0
6.6
P-Site Similarity:
100
N.A.
0
33.3
N.A.
100
40
N.A.
N.A.
33.3
26.6
33.3
N.A.
33.3
26.6
6.6
20
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
26.6
N.A.
N.A.
26.6
0
N.A.
P-Site Similarity:
66.6
N.A.
N.A.
60
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
27
0
0
7
0
0
14
0
7
14
0
0
0
% A
% Cys:
0
0
0
0
0
7
0
0
0
7
0
0
0
0
0
% C
% Asp:
0
7
0
0
0
0
0
7
7
0
0
0
0
0
0
% D
% Glu:
0
27
20
0
27
7
0
7
7
0
0
0
7
0
0
% E
% Phe:
0
0
0
0
0
0
14
0
0
14
0
0
0
14
14
% F
% Gly:
0
20
14
0
7
0
40
0
0
7
0
27
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
7
7
0
0
0
0
7
% H
% Ile:
7
0
7
7
20
0
0
14
7
14
14
0
7
7
0
% I
% Lys:
7
14
0
0
20
14
7
0
0
7
27
14
0
14
20
% K
% Leu:
7
7
0
40
7
0
0
7
27
20
0
0
34
14
0
% L
% Met:
0
0
0
0
0
7
0
0
0
0
0
0
0
7
0
% M
% Asn:
14
7
0
7
7
0
7
7
0
0
0
14
0
0
7
% N
% Pro:
7
0
0
0
0
0
0
14
14
0
7
7
14
7
7
% P
% Gln:
0
0
0
20
0
14
7
0
0
0
34
0
0
14
7
% Q
% Arg:
20
0
7
0
0
14
0
0
0
14
0
0
0
0
34
% R
% Ser:
14
7
7
0
0
20
7
7
7
0
7
14
0
0
0
% S
% Thr:
14
0
7
0
0
0
0
27
0
7
0
0
7
14
0
% T
% Val:
0
0
0
20
0
0
7
7
7
0
0
7
20
7
0
% V
% Trp:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
7
0
0
7
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _