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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
6.67
Human Site:
T731
Identified Species:
10.48
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
T731
R
L
D
M
A
P
D
T
L
Q
K
Q
A
D
H
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
V434
A
A
E
R
A
T
S
V
Y
L
V
Q
K
V
V
Dog
Lupus familis
XP_852722
879
98718
T729
L
P
D
M
E
P
D
T
L
Q
K
Q
A
D
H
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
Y719
L
L
A
A
A
L
G
Y
S
E
Q
P
D
V
E
Rat
Rattus norvegicus
Q5U2P0
1054
120741
L827
K
V
E
I
K
E
N
L
F
S
N
K
N
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S711
V
V
V
H
R
L
L
S
A
S
L
G
I
S
S
Frog
Xenopus laevis
Q6GN11
1040
119148
K819
K
D
H
L
L
G
N
K
D
L
E
E
L
C
R
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
L819
D
E
S
P
S
K
A
L
A
C
N
K
E
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
R895
H
F
T
S
P
I
R
R
Y
P
D
I
L
V
H
Honey Bee
Apis mellifera
XP_624734
786
91013
Y639
C
V
V
H
R
L
L
Y
S
T
M
K
N
V
E
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
E666
R
S
E
R
V
P
E
E
I
Q
E
I
C
T
R
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
H642
E
D
E
E
M
Y
R
H
Y
A
L
N
V
P
L
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
H712
D
N
M
N
D
W
G
H
Y
A
L
A
V
P
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
T835
L
Y
S
K
Q
K
Q
T
A
I
D
E
G
R
S
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
A854
R
R
Y
C
D
V
V
A
H
R
Q
L
A
G
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
13.3
80
N.A.
13.3
0
N.A.
N.A.
0
0
0
N.A.
6.6
0
20
0
P-Site Similarity:
100
N.A.
20
80
N.A.
26.6
40
N.A.
N.A.
13.3
33.3
13.3
N.A.
6.6
13.3
46.6
6.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
0
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
7
7
20
0
7
7
20
14
0
7
20
0
7
% A
% Cys:
7
0
0
7
0
0
0
0
0
7
0
0
7
7
0
% C
% Asp:
14
14
14
0
14
0
14
0
7
0
14
0
7
14
0
% D
% Glu:
7
7
27
7
7
7
7
7
0
7
14
14
7
0
27
% E
% Phe:
0
7
0
0
0
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
7
14
0
0
0
0
7
7
7
0
% G
% His:
7
0
7
14
0
0
0
14
7
0
0
0
0
0
20
% H
% Ile:
0
0
0
7
0
7
0
0
7
7
0
14
7
0
0
% I
% Lys:
14
0
0
7
7
14
0
7
0
0
14
20
7
0
0
% K
% Leu:
20
14
0
7
7
20
14
14
14
14
20
7
14
14
14
% L
% Met:
0
0
7
14
7
0
0
0
0
0
7
0
0
0
0
% M
% Asn:
0
7
0
7
0
0
14
0
0
0
14
7
14
0
0
% N
% Pro:
0
7
0
7
7
20
0
0
0
7
0
7
0
14
0
% P
% Gln:
0
0
0
0
7
0
7
0
0
20
14
20
0
0
0
% Q
% Arg:
20
7
0
14
14
0
14
7
0
7
0
0
0
7
14
% R
% Ser:
0
7
14
7
7
0
7
7
14
14
0
0
0
7
14
% S
% Thr:
0
0
7
0
0
7
0
20
0
7
0
0
0
7
0
% T
% Val:
7
20
14
0
7
7
7
7
0
0
7
0
14
27
7
% V
% Trp:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
7
0
0
7
0
14
27
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _