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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
7.58
Human Site:
T817
Identified Species:
11.9
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
T817
V
G
K
K
P
E
L
T
L
V
W
E
P
E
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
I516
P
A
K
E
L
P
P
I
S
P
E
H
S
S
E
Dog
Lupus familis
XP_852722
879
98718
T815
V
G
K
K
P
E
L
T
L
V
W
E
P
E
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
R801
Y
C
N
A
L
A
L
R
S
Y
S
F
Q
K
V
Rat
Rattus norvegicus
Q5U2P0
1054
120741
S918
I
S
C
G
P
E
G
S
S
E
W
K
P
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
A794
Q
K
R
I
Y
C
N
A
L
P
L
L
G
F
H
Frog
Xenopus laevis
Q6GN11
1040
119148
H911
D
G
Q
C
R
W
V
H
G
S
L
Q
R
L
P
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
A970
I
S
N
K
P
H
C
A
V
Q
P
E
S
Q
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
S979
M
N
V
V
T
L
E
S
G
H
V
I
S
I
N
Honey Bee
Apis mellifera
XP_624734
786
91013
I721
G
I
K
L
R
V
S
I
T
Q
L
E
K
L
A
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
A752
K
L
T
I
Y
W
P
A
D
P
N
A
E
S
G
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
A726
C
G
P
L
V
E
K
A
I
V
M
A
V
L
D
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
H795
L
S
A
A
A
L
K
H
R
I
P
C
P
E
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
D963
A
T
S
T
L
I
V
D
K
L
Y
S
K
R
G
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
E936
L
V
P
K
F
G
V
E
G
L
I
R
L
D
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
6.6
100
N.A.
6.6
26.6
N.A.
N.A.
6.6
6.6
20
N.A.
0
13.3
0
26.6
P-Site Similarity:
100
N.A.
20
100
N.A.
13.3
46.6
N.A.
N.A.
13.3
26.6
40
N.A.
20
13.3
0
33.3
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
13.3
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
7
14
7
7
0
27
0
0
0
14
0
0
7
% A
% Cys:
7
7
7
7
0
7
7
0
0
0
0
7
0
0
0
% C
% Asp:
7
0
0
0
0
0
0
7
7
0
0
0
0
7
20
% D
% Glu:
0
0
0
7
0
27
7
7
0
7
7
27
7
20
7
% E
% Phe:
0
0
0
0
7
0
0
0
0
0
0
7
0
7
0
% F
% Gly:
7
27
0
7
0
7
7
0
20
0
0
0
7
7
14
% G
% His:
0
0
0
0
0
7
0
14
0
7
0
7
0
0
7
% H
% Ile:
14
7
0
14
0
7
0
14
7
7
7
7
0
7
0
% I
% Lys:
7
7
27
27
0
0
14
0
7
0
0
7
14
7
0
% K
% Leu:
14
7
0
14
20
14
20
0
20
14
20
7
7
20
7
% L
% Met:
7
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% M
% Asn:
0
7
14
0
0
0
7
0
0
0
7
0
0
0
14
% N
% Pro:
7
0
14
0
27
7
14
0
0
20
14
0
27
0
14
% P
% Gln:
7
0
7
0
0
0
0
0
0
14
0
7
7
7
0
% Q
% Arg:
0
0
7
0
14
0
0
7
7
0
0
7
7
7
0
% R
% Ser:
0
20
7
0
0
0
7
14
20
7
7
7
20
14
7
% S
% Thr:
0
7
7
7
7
0
0
14
7
0
0
0
0
0
0
% T
% Val:
14
7
7
7
7
7
20
0
7
20
7
0
7
0
7
% V
% Trp:
0
0
0
0
0
14
0
0
0
0
20
0
0
0
0
% W
% Tyr:
7
0
0
0
14
0
0
0
0
7
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _