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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
2.73
Human Site:
T862
Identified Species:
4.29
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
T862
A
I
L
K
R
P
G
T
Q
G
H
L
G
P
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
F558
L
D
Q
L
K
L
A
F
T
L
D
H
E
T
G
Dog
Lupus familis
XP_852722
879
98718
R857
K
Y
S
A
I
L
K
R
P
G
T
E
G
L
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
Q843
S
L
V
D
V
V
L
Q
A
E
A
T
A
L
K
Rat
Rattus norvegicus
Q5U2P0
1054
120741
G1015
Q
L
A
Q
E
V
K
G
K
V
I
E
E
E
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
E836
I
T
I
F
T
L
V
E
V
V
L
R
S
D
G
Frog
Xenopus laevis
Q6GN11
1040
119148
V999
A
V
E
A
Q
L
A
V
E
G
A
A
E
L
K
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
S1033
Y
V
L
L
Q
E
I
S
E
L
A
L
M
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
V1022
R
K
L
Q
L
L
S
V
V
P
I
C
L
I
I
Honey Bee
Apis mellifera
XP_624734
786
91013
I764
F
S
L
L
Y
L
R
I
E
K
H
P
E
S
F
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
L795
A
T
I
V
R
P
S
L
E
Q
R
N
I
L
K
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
E777
L
T
L
E
W
E
D
E
A
G
S
K
G
V
T
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
V838
V
S
V
K
R
K
E
V
L
L
S
D
A
R
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
S1010
T
E
S
P
E
A
V
S
I
D
E
V
A
P
A
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
V979
D
V
Y
V
F
D
K
V
E
V
Q
V
R
S
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
13.3
N.A.
0
0
N.A.
N.A.
0
13.3
13.3
N.A.
6.6
13.3
20
20
P-Site Similarity:
100
N.A.
6.6
13.3
N.A.
26.6
20
N.A.
N.A.
6.6
40
40
N.A.
13.3
20
40
26.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
13.3
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
20
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
7
14
0
7
14
0
14
0
20
7
20
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% C
% Asp:
7
7
0
7
0
7
7
0
0
7
7
7
0
14
0
% D
% Glu:
0
7
7
7
14
14
7
14
34
7
7
14
27
7
7
% E
% Phe:
7
0
0
7
7
0
0
7
0
0
0
0
0
0
7
% F
% Gly:
0
0
0
0
0
0
7
7
0
27
0
0
20
0
14
% G
% His:
0
0
0
0
0
0
0
0
0
0
14
7
0
0
7
% H
% Ile:
7
7
14
0
7
0
7
7
7
0
14
0
7
7
7
% I
% Lys:
7
7
0
14
7
7
20
0
7
7
0
7
0
0
20
% K
% Leu:
14
14
34
20
7
40
7
7
7
20
7
14
7
27
14
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% N
% Pro:
0
0
0
7
0
14
0
0
7
7
0
7
0
14
0
% P
% Gln:
7
0
7
14
14
0
0
7
7
7
7
0
0
0
0
% Q
% Arg:
7
0
0
0
20
0
7
7
0
0
7
7
7
7
0
% R
% Ser:
7
14
14
0
0
0
14
14
0
0
14
0
7
14
0
% S
% Thr:
7
20
0
0
7
0
0
7
7
0
7
7
0
7
7
% T
% Val:
7
20
14
14
7
14
14
27
14
20
0
14
0
7
14
% V
% Trp:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
7
7
0
7
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _