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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
16.67
Human Site:
Y279
Identified Species:
26.19
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
Y279
D
H
R
V
P
R
I
Y
V
P
L
K
D
C
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
K45
K
N
K
S
T
R
G
K
K
K
S
I
F
E
T
Dog
Lupus familis
XP_852722
879
98718
Y277
D
H
R
V
P
R
I
Y
V
P
L
K
D
C
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
Y277
D
H
R
V
P
R
I
Y
V
P
L
K
D
C
P
Rat
Rattus norvegicus
Q5U2P0
1054
120741
G336
M
P
T
G
R
V
V
G
I
L
Q
K
N
W
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
Y274
D
H
R
V
P
R
A
Y
V
S
L
A
D
C
P
Frog
Xenopus laevis
Q6GN11
1040
119148
Y367
V
L
V
M
P
W
D
Y
R
I
P
K
I
R
I
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
D365
K
I
L
V
V
P
W
D
Y
R
I
P
K
I
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
S386
E
I
S
G
G
K
P
S
L
S
L
A
D
G
E
Honey Bee
Apis mellifera
XP_624734
786
91013
E250
N
I
G
D
I
R
T
E
S
N
A
I
L
L
E
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
L252
D
G
R
L
V
K
L
L
G
M
S
G
E
I
D
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
D249
T
F
S
Q
R
P
Q
D
Y
A
N
T
L
F
I
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
Y283
L
S
I
S
N
R
E
Y
I
E
M
M
P
T
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
I381
D
P
R
F
P
K
L
I
V
P
F
H
V
L
P
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
R435
D
K
C
L
P
K
V
R
I
R
T
R
R
A
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
6.6
100
N.A.
100
6.6
N.A.
N.A.
80
20
6.6
N.A.
13.3
6.6
13.3
0
P-Site Similarity:
100
N.A.
20
100
N.A.
100
26.6
N.A.
N.A.
80
26.6
13.3
N.A.
33.3
13.3
40
0
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
13.3
N.A.
N.A.
40
13.3
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
53.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
0
0
7
7
14
0
7
7
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
0
0
27
0
% C
% Asp:
47
0
0
7
0
0
7
14
0
0
0
0
34
0
14
% D
% Glu:
7
0
0
0
0
0
7
7
0
7
0
0
7
7
14
% E
% Phe:
0
7
0
7
0
0
0
0
0
0
7
0
7
7
0
% F
% Gly:
0
7
7
14
7
0
7
7
7
0
0
7
0
7
0
% G
% His:
0
27
0
0
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
0
20
7
0
7
0
20
7
20
7
7
14
7
14
14
% I
% Lys:
14
7
7
0
0
27
0
7
7
7
0
34
7
0
0
% K
% Leu:
7
7
7
14
0
0
14
7
7
7
34
0
14
14
0
% L
% Met:
7
0
0
7
0
0
0
0
0
7
7
7
0
0
0
% M
% Asn:
7
7
0
0
7
0
0
0
0
7
7
0
7
0
0
% N
% Pro:
0
14
0
0
47
14
7
0
0
27
7
7
7
0
34
% P
% Gln:
0
0
0
7
0
0
7
0
0
0
7
0
0
0
0
% Q
% Arg:
0
0
40
0
14
47
0
7
7
14
0
7
7
7
14
% R
% Ser:
0
7
14
14
0
0
0
7
7
14
14
0
0
0
0
% S
% Thr:
7
0
7
0
7
0
7
0
0
0
7
7
0
7
7
% T
% Val:
7
0
7
34
14
7
14
0
34
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
7
7
0
0
0
0
0
0
7
0
% W
% Tyr:
0
0
0
0
0
0
0
40
14
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _