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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
14.85
Human Site:
Y340
Identified Species:
23.33
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
Y340
T
E
G
I
L
T
E
Y
G
V
D
F
S
D
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
I96
D
G
D
R
D
I
F
I
D
G
V
V
A
R
N
Dog
Lupus familis
XP_852722
879
98718
Y338
T
E
G
I
L
T
E
Y
G
V
D
F
S
D
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
Y338
T
E
G
I
L
T
E
Y
G
V
D
F
S
D
F
Rat
Rattus norvegicus
Q5U2P0
1054
120741
V435
L
V
E
N
S
I
N
V
V
P
F
S
E
A
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
Y335
T
E
G
I
L
T
E
Y
G
V
D
F
S
D
F
Frog
Xenopus laevis
Q6GN11
1040
119148
S429
I
L
V
E
N
S
I
S
L
N
P
F
S
E
A
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
V429
L
V
E
N
C
I
H
V
P
P
F
S
E
A
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
N529
L
K
A
I
L
F
H
N
G
L
R
D
I
K
P
Honey Bee
Apis mellifera
XP_624734
786
91013
P301
E
C
I
F
T
I
D
P
D
A
A
V
D
L
D
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
R319
T
I
D
P
K
T
A
R
D
L
D
D
A
L
H
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
F301
H
G
I
D
S
S
E
F
T
T
E
V
L
E
D
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
E361
Q
I
N
A
I
L
H
E
N
A
I
C
C
S
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
Q445
Q
I
N
A
I
L
Y
Q
N
S
V
C
D
S
D
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
H488
T
E
A
L
L
L
E
H
D
V
E
Y
R
P
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
100
N.A.
100
0
N.A.
N.A.
100
13.3
0
N.A.
20
0
20
6.6
P-Site Similarity:
100
N.A.
6.6
100
N.A.
100
0
N.A.
N.A.
100
26.6
0
N.A.
33.3
6.6
33.3
33.3
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
0
N.A.
N.A.
0
40
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
6.6
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
14
14
0
0
7
0
0
14
7
0
14
14
7
% A
% Cys:
0
7
0
0
7
0
0
0
0
0
0
14
7
0
0
% C
% Asp:
7
0
14
7
7
0
7
0
27
0
34
14
14
27
20
% D
% Glu:
7
34
14
7
0
0
40
7
0
0
14
0
14
14
0
% E
% Phe:
0
0
0
7
0
7
7
7
0
0
14
34
0
0
34
% F
% Gly:
0
14
27
0
0
0
0
0
34
7
0
0
0
0
0
% G
% His:
7
0
0
0
0
0
20
7
0
0
0
0
0
0
7
% H
% Ile:
7
20
14
34
14
27
7
7
0
0
7
0
7
0
0
% I
% Lys:
0
7
0
0
7
0
0
0
0
0
0
0
0
7
7
% K
% Leu:
20
7
0
7
40
20
0
0
7
14
0
0
7
14
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
14
14
7
0
7
7
14
7
0
0
0
0
7
% N
% Pro:
0
0
0
7
0
0
0
7
7
14
7
0
0
7
7
% P
% Gln:
14
0
0
0
0
0
0
7
0
0
0
0
0
0
14
% Q
% Arg:
0
0
0
7
0
0
0
7
0
0
7
0
7
7
0
% R
% Ser:
0
0
0
0
14
14
0
7
0
7
0
14
34
14
0
% S
% Thr:
40
0
0
0
7
34
0
0
7
7
0
0
0
0
0
% T
% Val:
0
14
7
0
0
0
0
14
7
34
14
20
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
27
0
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _