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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
40.3
Human Site:
Y494
Identified Species:
63.33
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
Y494
R
S
C
T
K
L
S
Y
E
H
A
Q
S
M
I
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
K242
V
V
Y
I
L
E
K
K
H
S
R
A
A
T
G
Dog
Lupus familis
XP_852722
879
98718
Y492
R
S
C
T
K
L
S
Y
E
H
A
Q
S
M
I
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
Y492
R
S
C
T
K
L
S
Y
D
H
A
Q
S
M
I
Rat
Rattus norvegicus
Q5U2P0
1054
120741
Y590
R
S
A
Y
K
L
F
Y
E
A
A
Q
E
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
Y489
C
S
C
A
K
L
S
Y
D
H
A
Q
S
M
I
Frog
Xenopus laevis
Q6GN11
1040
119148
Y584
R
S
S
Y
K
L
S
Y
E
V
A
Q
Q
L
L
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
Y585
R
S
S
Y
Q
L
H
Y
E
L
A
Q
S
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
Y684
N
S
C
S
Q
F
A
Y
E
H
A
Q
K
I
I
Honey Bee
Apis mellifera
XP_624734
786
91013
L447
L
S
I
K
V
N
I
L
H
N
L
A
I
Q
M
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
M468
E
I
K
E
K
T
L
M
L
H
R
I
A
Q
V
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
Y448
R
S
C
V
K
L
S
Y
L
H
A
Q
D
M
I
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
Y515
Q
S
C
C
K
L
S
Y
E
H
A
Q
G
I
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
Y599
R
S
C
C
K
L
S
Y
D
H
A
Q
D
I
I
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
Y654
R
S
R
E
A
F
S
Y
E
Q
A
Q
L
R
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
100
N.A.
93.3
53.3
N.A.
N.A.
80
60
53.3
N.A.
53.3
6.6
13.3
80
P-Site Similarity:
100
N.A.
6.6
100
N.A.
100
66.6
N.A.
N.A.
86.6
73.3
73.3
N.A.
80
20
26.6
80
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
66.6
N.A.
N.A.
73.3
53.3
N.A.
P-Site Similarity:
86.6
N.A.
N.A.
86.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
7
0
7
0
0
7
80
14
14
0
0
% A
% Cys:
7
0
54
14
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
20
0
0
0
14
0
0
% D
% Glu:
7
0
0
14
0
7
0
0
54
0
0
0
7
0
0
% E
% Phe:
0
0
0
0
0
14
7
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
7
% G
% His:
0
0
0
0
0
0
7
0
14
60
0
0
0
0
0
% H
% Ile:
0
7
7
7
0
0
7
0
0
0
0
7
7
20
54
% I
% Lys:
0
0
7
7
67
0
7
7
0
0
0
0
7
0
0
% K
% Leu:
7
0
0
0
7
67
7
7
14
7
7
0
7
20
20
% L
% Met:
0
0
0
0
0
0
0
7
0
0
0
0
0
34
7
% M
% Asn:
7
0
0
0
0
7
0
0
0
7
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
7
0
0
0
14
0
0
0
0
7
0
80
7
14
0
% Q
% Arg:
60
0
7
0
0
0
0
0
0
0
14
0
0
7
0
% R
% Ser:
0
87
14
7
0
0
60
0
0
7
0
0
34
0
0
% S
% Thr:
0
0
0
20
0
7
0
0
0
0
0
0
0
7
0
% T
% Val:
7
7
0
7
7
0
0
0
0
7
0
0
0
0
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
20
0
0
0
80
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _