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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
13.64
Human Site:
Y575
Identified Species:
21.43
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
Y575
Q
G
C
H
I
Y
E
Y
R
E
S
N
K
L
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
F301
K
D
Y
A
N
T
L
F
I
C
R
I
V
D
W
Dog
Lupus familis
XP_852722
879
98718
Y573
Q
G
C
H
I
Y
E
Y
R
D
S
N
K
L
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
Y573
Q
G
C
H
I
Y
E
Y
R
D
S
N
K
L
V
Rat
Rattus norvegicus
Q5U2P0
1054
120741
V654
G
A
L
E
L
E
G
V
E
V
R
V
Q
L
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
Y570
Q
G
C
Y
I
Y
Q
Y
R
D
S
N
K
L
V
Frog
Xenopus laevis
Q6GN11
1040
119148
H656
R
V
Q
L
G
E
K
H
S
I
D
D
L
V
P
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
V646
G
A
L
E
L
E
G
V
E
V
R
A
Q
L
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
E756
L
L
D
P
I
T
G
E
P
L
S
F
E
V
E
Honey Bee
Apis mellifera
XP_624734
786
91013
M506
E
F
M
L
L
A
N
M
T
V
A
T
Q
L
Y
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
M527
E
F
M
L
L
A
N
M
E
V
A
K
K
I
A
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
V508
G
A
L
R
L
D
Q
V
K
L
Q
Y
S
L
N
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
R575
R
F
D
N
G
A
L
R
L
E
S
S
K
I
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
R678
Y
D
F
V
T
C
S
R
K
G
S
N
F
L
V
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
L720
N
E
V
E
I
K
K
L
L
A
T
N
S
L
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
93.3
N.A.
93.3
6.6
N.A.
N.A.
80
0
6.6
N.A.
13.3
6.6
6.6
6.6
P-Site Similarity:
100
N.A.
13.3
100
N.A.
100
20
N.A.
N.A.
100
33.3
20
N.A.
26.6
33.3
33.3
26.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
26.6
N.A.
N.A.
26.6
26.6
N.A.
P-Site Similarity:
53.3
N.A.
N.A.
33.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
20
0
7
0
20
0
0
0
7
14
7
0
0
7
% A
% Cys:
0
0
27
0
0
7
0
0
0
7
0
0
0
0
0
% C
% Asp:
0
14
14
0
0
7
0
0
0
20
7
7
0
7
14
% D
% Glu:
14
7
0
20
0
20
20
7
20
14
0
0
7
0
7
% E
% Phe:
0
20
7
0
0
0
0
7
0
0
0
7
7
0
0
% F
% Gly:
20
27
0
0
14
0
20
0
0
7
0
0
0
0
0
% G
% His:
0
0
0
20
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
40
0
0
0
7
7
0
7
0
14
0
% I
% Lys:
7
0
0
0
0
7
14
0
14
0
0
7
40
0
0
% K
% Leu:
7
7
20
20
34
0
14
7
14
14
0
0
7
67
0
% L
% Met:
0
0
14
0
0
0
0
14
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
7
7
0
14
0
0
0
0
40
0
0
7
% N
% Pro:
0
0
0
7
0
0
0
0
7
0
0
0
0
0
7
% P
% Gln:
27
0
7
0
0
0
14
0
0
0
7
0
20
0
0
% Q
% Arg:
14
0
0
7
0
0
0
14
27
0
20
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
7
0
7
0
47
7
14
0
0
% S
% Thr:
0
0
0
0
7
14
0
0
7
0
7
7
0
0
0
% T
% Val:
0
7
7
7
0
0
0
20
0
27
0
7
7
14
47
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
7
0
7
7
0
27
0
27
0
0
0
7
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _