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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
16.06
Human Site:
Y689
Identified Species:
25.24
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
Y689
D
P
A
Q
F
R
H
Y
A
L
N
V
P
L
Y
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
D392
S
T
A
R
D
L
D
D
A
L
S
C
K
P
L
Dog
Lupus familis
XP_852722
879
98718
Y687
D
Q
A
Q
F
R
H
Y
A
L
N
V
P
L
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
M677
A
L
Y
F
C
S
G
M
L
Q
D
Q
E
Q
F
Rat
Rattus norvegicus
Q5U2P0
1054
120741
Y785
A
E
E
E
F
H
H
Y
G
L
A
L
D
K
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
Y669
R
P
M
Q
M
A
L
Y
F
C
T
G
V
L
K
Frog
Xenopus laevis
Q6GN11
1040
119148
Y777
T
E
D
E
F
Y
H
Y
G
L
A
L
E
K
Y
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
Y777
P
E
E
Q
Y
Y
H
Y
G
L
A
L
A
R
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
Q853
A
M
N
A
C
L
S
Q
L
L
M
K
P
M
A
Honey Bee
Apis mellifera
XP_624734
786
91013
Y597
K
A
M
T
R
A
T
Y
I
C
S
S
T
V
T
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
F624
P
L
S
F
Y
H
H
F
A
L
N
V
D
H
Y
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
R600
K
L
Q
A
S
L
N
R
Y
C
T
S
E
E
Q
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
I670
F
Q
Q
S
L
E
R
I
K
E
K
L
K
D
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
Y793
S
V
A
E
W
G
H
Y
A
L
A
V
P
L
Y
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
C812
V
R
I
M
S
T
R
C
M
M
A
A
Q
Y
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
20
93.3
N.A.
0
33.3
N.A.
N.A.
26.6
33.3
33.3
N.A.
13.3
6.6
40
0
P-Site Similarity:
100
N.A.
33.3
93.3
N.A.
13.3
46.6
N.A.
N.A.
26.6
46.6
46.6
N.A.
20
20
60
6.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
0
N.A.
N.A.
60
0
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
73.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
7
27
14
0
14
0
0
34
0
34
7
7
0
7
% A
% Cys:
0
0
0
0
14
0
0
7
0
20
0
7
0
0
0
% C
% Asp:
14
0
7
0
7
0
7
7
0
0
7
0
14
7
7
% D
% Glu:
0
20
14
20
0
7
0
0
0
7
0
0
20
7
0
% E
% Phe:
7
0
0
14
27
0
0
7
7
0
0
0
0
0
14
% F
% Gly:
0
0
0
0
0
7
7
0
20
0
0
7
0
0
0
% G
% His:
0
0
0
0
0
14
47
0
0
0
0
0
0
7
0
% H
% Ile:
0
0
7
0
0
0
0
7
7
0
0
0
0
0
0
% I
% Lys:
14
0
0
0
0
0
0
0
7
0
7
7
14
14
7
% K
% Leu:
0
20
0
0
7
20
7
0
14
60
0
27
0
27
7
% L
% Met:
0
7
14
7
7
0
0
7
7
7
7
0
0
7
0
% M
% Asn:
0
0
7
0
0
0
7
0
0
0
20
0
0
0
0
% N
% Pro:
14
14
0
0
0
0
0
0
0
0
0
0
27
7
0
% P
% Gln:
0
14
14
27
0
0
0
7
0
7
0
7
7
7
7
% Q
% Arg:
7
7
0
7
7
14
14
7
0
0
0
0
0
7
0
% R
% Ser:
14
0
7
7
14
7
7
0
0
0
14
14
0
0
0
% S
% Thr:
7
7
0
7
0
7
7
0
0
0
14
0
7
0
7
% T
% Val:
7
7
0
0
0
0
0
0
0
0
0
27
7
7
0
% V
% Trp:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
14
14
0
54
7
0
0
0
0
7
47
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _