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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
12.12
Human Site:
Y796
Identified Species:
19.05
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
Y796
Y
G
V
Q
K
R
I
Y
C
N
A
L
A
L
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
E495
S
C
T
K
L
S
Y
E
H
A
Q
S
M
I
E
Dog
Lupus familis
XP_852722
879
98718
Y794
Y
G
V
Q
K
R
I
Y
C
N
A
L
P
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
F780
M
G
V
L
N
Q
A
F
D
V
L
V
L
R
F
Rat
Rattus norvegicus
Q5U2P0
1054
120741
I897
V
F
I
P
R
F
G
I
K
G
A
A
Y
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
L773
E
A
M
V
M
G
V
L
N
E
A
F
D
V
L
Frog
Xenopus laevis
Q6GN11
1040
119148
Y890
Y
G
I
K
G
A
A
Y
L
K
N
T
D
G
L
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
E949
V
T
V
R
I
S
V
E
P
S
R
C
H
A
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
I958
Y
V
H
N
K
Q
G
I
Y
M
R
A
V
V
I
Honey Bee
Apis mellifera
XP_624734
786
91013
N700
V
T
M
G
I
V
L
N
V
N
E
N
F
I
N
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
Y731
Y
G
V
V
K
R
V
Y
V
D
K
M
K
R
D
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
D705
D
S
A
K
E
V
S
D
K
S
S
D
L
F
F
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
F774
R
C
F
T
G
I
C
F
C
K
D
V
A
E
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
Y942
L
G
I
E
R
R
I
Y
Y
D
Q
I
E
G
L
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
T915
R
N
N
E
S
T
E
T
G
Y
V
I
K
V
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
93.3
N.A.
13.3
13.3
N.A.
N.A.
6.6
20
6.6
N.A.
13.3
6.6
40
0
P-Site Similarity:
100
N.A.
13.3
93.3
N.A.
33.3
33.3
N.A.
N.A.
26.6
33.3
26.6
N.A.
26.6
26.6
60
26.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
13.3
N.A.
N.A.
26.6
0
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
60
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
0
7
14
0
0
7
27
14
14
7
0
% A
% Cys:
0
14
0
0
0
0
7
0
20
0
0
7
0
0
0
% C
% Asp:
7
0
0
0
0
0
0
7
7
14
7
7
14
0
14
% D
% Glu:
7
0
0
14
7
0
7
14
0
7
7
0
7
7
7
% E
% Phe:
0
7
7
0
0
7
0
14
0
0
0
7
7
7
20
% F
% Gly:
0
40
0
7
14
7
14
0
7
7
0
0
0
14
0
% G
% His:
0
0
7
0
0
0
0
0
7
0
0
0
7
0
0
% H
% Ile:
0
0
20
0
14
7
20
14
0
0
0
14
0
14
7
% I
% Lys:
0
0
0
20
27
0
0
0
14
14
7
0
14
0
7
% K
% Leu:
7
0
0
7
7
0
7
7
7
0
7
14
14
20
20
% L
% Met:
7
0
14
0
7
0
0
0
0
7
0
7
7
0
0
% M
% Asn:
0
7
7
7
7
0
0
7
7
20
7
7
0
0
7
% N
% Pro:
0
0
0
7
0
0
0
0
7
0
0
0
7
0
0
% P
% Gln:
0
0
0
14
0
14
0
0
0
0
14
0
0
0
0
% Q
% Arg:
14
0
0
7
14
27
0
0
0
0
14
0
0
14
14
% R
% Ser:
7
7
0
0
7
14
7
0
0
14
7
7
0
0
7
% S
% Thr:
0
14
7
7
0
7
0
7
0
0
0
7
0
0
0
% T
% Val:
20
7
34
14
0
14
20
0
14
7
7
14
7
20
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
34
0
0
0
0
0
7
34
14
7
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _