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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GSPT2
All Species:
4.24
Human Site:
S189
Identified Species:
7.78
UniProt:
Q8IYD1
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.5
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYD1
NP_060564.2
628
68883
S189
E
K
E
E
I
R
K
S
K
S
V
I
V
P
S
Chimpanzee
Pan troglodytes
XP_001140542
404
45524
K8
Y
L
T
G
M
V
D
K
R
T
L
E
K
Y
E
Rhesus Macaque
Macaca mulatta
XP_001100703
624
68653
S185
E
K
E
E
I
R
K
S
K
Y
M
I
V
P
S
Dog
Lupus familis
XP_538042
627
69152
K189
K
E
E
V
R
K
S
K
S
V
M
V
P
S
G
Cat
Felis silvestris
Mouse
Mus musculus
Q149F3
632
69128
K194
K
E
E
V
R
K
S
K
S
V
S
I
P
S
G
Rat
Rattus norvegicus
Q6AXM7
679
74756
K243
L
R
Q
Q
I
D
V
K
A
G
L
E
K
R
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517098
414
45834
A18
E
A
F
S
G
D
G
A
E
E
P
L
P
D
G
Chicken
Gallus gallus
NP_001129149
618
67640
P185
K
P
K
S
V
V
A
P
P
G
A
P
K
K
E
Frog
Xenopus laevis
NP_001086960
553
61252
K157
Y
L
T
G
M
V
E
K
R
T
L
E
K
Y
E
Zebra Danio
Brachydanio rerio
NP_942101
577
63652
K181
Y
L
T
G
M
V
D
K
R
T
L
E
K
Y
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477259
619
66434
K182
T
P
K
V
S
K
K
K
V
V
K
V
E
E
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785469
575
63867
G179
H
I
M
Y
L
T
G
G
V
D
K
R
T
L
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P05453
685
76532
D247
K
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
62.4
98.7
94.1
N.A.
89.7
33.5
N.A.
62.5
85.1
75.6
73
N.A.
54.6
N.A.
N.A.
59.7
Protein Similarity:
100
63.2
99
95.8
N.A.
93.9
51.5
N.A.
64.3
88.8
81.6
79.7
N.A.
67.6
N.A.
N.A.
72.9
P-Site Identity:
100
0
86.6
6.6
N.A.
13.3
6.6
N.A.
6.6
0
0
0
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
26.6
93.3
40
N.A.
33.3
33.3
N.A.
26.6
20
33.3
26.6
N.A.
33.3
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
42.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
59.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
8
8
8
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
16
16
8
8
8
0
0
0
16
0
% D
% Glu:
24
24
31
24
8
8
8
0
8
16
0
31
8
8
39
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
24
8
0
16
8
0
16
0
0
0
0
24
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
24
0
0
0
0
0
0
24
0
0
0
% I
% Lys:
31
16
16
0
0
24
24
54
16
0
16
0
39
8
0
% K
% Leu:
8
24
0
0
8
0
0
0
0
0
31
8
0
8
0
% L
% Met:
0
0
8
0
24
0
0
0
0
0
16
0
0
0
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% N
% Pro:
0
16
0
0
0
0
0
8
8
0
8
8
24
16
0
% P
% Gln:
0
0
16
8
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
8
0
0
16
16
0
0
24
0
0
8
0
8
0
% R
% Ser:
0
0
0
16
8
0
16
16
16
8
8
0
0
16
16
% S
% Thr:
8
0
24
0
0
8
0
0
0
24
0
0
8
0
0
% T
% Val:
0
0
0
24
8
31
16
0
16
24
16
24
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
24
0
0
8
0
0
0
0
0
8
0
0
0
24
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _