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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FANCM All Species: 10.3
Human Site: S1154 Identified Species: 28.33
UniProt: Q8IYD8 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IYD8 NP_065988.1 2048 232191 S1154 V S L S P L N S K S E S L P V
Chimpanzee Pan troglodytes XP_509928 2048 232151 S1154 V S L S P L N S K S K S L P V
Rhesus Macaque Macaca mulatta XP_001096802 2050 232308 S1154 V S L A P L N S K S K S L R V
Dog Lupus familis XP_537429 2047 232355 N1152 L S L S P S N N K Y K S S G V
Cat Felis silvestris
Mouse Mus musculus Q8BGE5 2021 225999 I1123 F E D D F K N I E D G P E E L
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001171151 2166 244429 E1255 E S Q D K E N E N F A S Q V N
Zebra Danio Brachydanio rerio NP_001107132 1761 197421 L899 S F S L T S A L G D P D E D D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781239 2463 274499 S1345 I R G A A V C S P G N E L L K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_174785 1324 148336 V462 I L V D H F K V K D P K T S R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 94.2 79.4 N.A. 65.2 N.A. N.A. N.A. N.A. 44 38 N.A. N.A. N.A. N.A. 31.2
Protein Similarity: 100 99.2 96.6 87.5 N.A. 76.2 N.A. N.A. N.A. N.A. 60.1 55.4 N.A. N.A. N.A. N.A. 49.1
P-Site Identity: 100 93.3 80 53.3 N.A. 6.6 N.A. N.A. N.A. N.A. 20 0 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 93.3 73.3 N.A. 20 N.A. N.A. N.A. N.A. 20 0 N.A. N.A. N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. 25.7 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 40 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 23 12 0 12 0 0 0 12 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 12 34 0 0 0 0 0 34 0 12 0 12 12 % D
% Glu: 12 12 0 0 0 12 0 12 12 0 12 12 23 12 0 % E
% Phe: 12 12 0 0 12 12 0 0 0 12 0 0 0 0 0 % F
% Gly: 0 0 12 0 0 0 0 0 12 12 12 0 0 12 0 % G
% His: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 23 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 12 12 12 0 56 0 34 12 0 0 12 % K
% Leu: 12 12 45 12 0 34 0 12 0 0 0 0 45 12 12 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 67 12 12 0 12 0 0 0 12 % N
% Pro: 0 0 0 0 45 0 0 0 12 0 23 12 0 23 0 % P
% Gln: 0 0 12 0 0 0 0 0 0 0 0 0 12 0 0 % Q
% Arg: 0 12 0 0 0 0 0 0 0 0 0 0 0 12 12 % R
% Ser: 12 56 12 34 0 23 0 45 0 34 0 56 12 12 0 % S
% Thr: 0 0 0 0 12 0 0 0 0 0 0 0 12 0 0 % T
% Val: 34 0 12 0 0 12 0 12 0 0 0 0 0 12 45 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 12 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _