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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HACE1 All Species: 29.39
Human Site: S566 Identified Species: 64.67
UniProt: Q8IYU2 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IYU2 NP_065822.2 909 102342 S566 R D S I F R S S C E V V S K A
Chimpanzee Pan troglodytes XP_518654 909 102309 S566 R D S I F R S S C E V V S K A
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_854232 909 102021 S566 R D S I F R S S C E V V S K A
Cat Felis silvestris
Mouse Mus musculus Q3U0D9 909 102095 S566 R D S I F R S S C E I V S K A
Rat Rattus norvegicus NP_001102009 909 102140 S566 R D S I F R S S C E I V S K A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506045 1055 117889 S712 R D S I F R S S C E V V S K A
Chicken Gallus gallus NP_001026249 636 71705 F331 V R I F C H V F R I G P S S P
Frog Xenopus laevis Q6DCL5 944 106566 S601 R D S I F R S S C E V V F K S
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 Y460 G V A R E W L Y L L S H E M L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9Y0H4 949 107948 S607 R Q T L F E D S Y H Q I M R L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002301117 471 53841 F166 Q L L S R V I F D K G A L L F
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 N.A. 98.3 N.A. 97.1 96.9 N.A. 81.9 47.8 87.1 26.2 N.A. 24.5 N.A. N.A. N.A.
Protein Similarity: 100 99.8 N.A. 99.2 N.A. 98.7 98.9 N.A. 84 56.4 91.2 43.5 N.A. 40.7 N.A. N.A. N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 93.3 93.3 N.A. 100 6.6 86.6 0 N.A. 20 N.A. N.A. N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 6.6 93.3 6.6 N.A. 46.6 N.A. N.A. N.A.
Percent
Protein Identity: 23.8 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 36.9 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 13.3 N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 0 0 0 0 0 10 0 0 55 % A
% Cys: 0 0 0 0 10 0 0 0 64 0 0 0 0 0 0 % C
% Asp: 0 64 0 0 0 0 10 0 10 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 10 10 0 0 0 64 0 0 10 0 0 % E
% Phe: 0 0 0 10 73 0 0 19 0 0 0 0 10 0 10 % F
% Gly: 10 0 0 0 0 0 0 0 0 0 19 0 0 0 0 % G
% His: 0 0 0 0 0 10 0 0 0 10 0 10 0 0 0 % H
% Ile: 0 0 10 64 0 0 10 0 0 10 19 10 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 10 0 0 0 64 0 % K
% Leu: 0 10 10 10 0 0 10 0 10 10 0 0 10 10 19 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 10 10 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 10 % P
% Gln: 10 10 0 0 0 0 0 0 0 0 10 0 0 0 0 % Q
% Arg: 73 10 0 10 10 64 0 0 10 0 0 0 0 10 0 % R
% Ser: 0 0 64 10 0 0 64 73 0 0 10 0 64 10 10 % S
% Thr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 10 10 0 0 0 10 10 0 0 0 46 64 0 0 0 % V
% Trp: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 10 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _