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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC22A15
All Species:
22.42
Human Site:
S259
Identified Species:
44.85
UniProt:
Q8IZD6
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IZD6
NP_060890.2
547
60540
S259
L
Y
S
Q
G
R
L
S
E
A
E
E
A
L
Y
Chimpanzee
Pan troglodytes
XP_524810
547
60491
S259
L
Y
S
Q
G
R
L
S
E
A
E
E
A
L
Y
Rhesus Macaque
Macaca mulatta
XP_001112207
547
60489
S259
L
Y
S
Q
G
R
L
S
E
A
E
E
A
L
Y
Dog
Lupus familis
XP_540254
585
64648
S297
L
Y
S
Q
G
R
L
S
E
A
E
A
A
L
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q504N2
544
60273
S259
L
Y
S
Q
G
R
L
S
E
A
E
E
A
L
Y
Rat
Rattus norvegicus
O70594
557
62549
L260
I
R
D
W
R
M
L
L
L
A
L
T
V
P
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510903
488
53593
Y208
F
A
V
G
I
A
F
Y
A
I
L
G
Y
C
I
Chicken
Gallus gallus
XP_416558
546
60154
S259
L
Y
S
Q
G
R
L
S
E
A
E
D
A
L
Y
Frog
Xenopus laevis
Q6NUB3
531
58000
A251
A
Q
G
R
L
H
E
A
Q
E
S
L
V
S
L
Zebra Danio
Brachydanio rerio
NP_001103169
497
54650
L216
C
P
G
L
L
L
F
L
L
C
V
T
L
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCA2
548
60985
W262
L
L
F
L
C
Y
Y
W
I
I
P
E
S
A
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U539
585
65444
A302
S
V
S
V
G
K
W
A
D
A
K
K
Q
L
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
84.4
N.A.
93.4
31.4
N.A.
43.6
87.1
58.3
45.3
N.A.
33.3
N.A.
25.9
N.A.
Protein Similarity:
100
99.8
99.6
89
N.A.
96.8
52.4
N.A.
58.3
92.5
75.1
65.2
N.A.
54.2
N.A.
48.7
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
100
13.3
N.A.
0
93.3
0
0
N.A.
13.3
N.A.
26.6
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
20
N.A.
0
100
20
0
N.A.
20
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
0
0
9
0
17
9
67
0
9
50
9
0
% A
% Cys:
9
0
0
0
9
0
0
0
0
9
0
0
0
9
0
% C
% Asp:
0
0
9
0
0
0
0
0
9
0
0
9
0
0
0
% D
% Glu:
0
0
0
0
0
0
9
0
50
9
50
42
0
0
9
% E
% Phe:
9
0
9
0
0
0
17
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
17
9
59
0
0
0
0
0
0
9
0
0
9
% G
% His:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
0
0
0
9
0
0
0
9
17
0
0
0
0
9
% I
% Lys:
0
0
0
0
0
9
0
0
0
0
9
9
0
0
9
% K
% Leu:
59
9
0
17
17
9
59
17
17
0
17
9
9
59
9
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
9
0
0
0
0
0
0
0
0
9
0
0
17
0
% P
% Gln:
0
9
0
50
0
0
0
0
9
0
0
0
9
0
0
% Q
% Arg:
0
9
0
9
9
50
0
0
0
0
0
0
0
0
9
% R
% Ser:
9
0
59
0
0
0
0
50
0
0
9
0
9
9
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
17
0
0
0
% T
% Val:
0
9
9
9
0
0
0
0
0
0
9
0
17
0
0
% V
% Trp:
0
0
0
9
0
0
9
9
0
0
0
0
0
0
0
% W
% Tyr:
0
50
0
0
0
9
9
9
0
0
0
0
9
0
50
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _