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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC22A15
All Species:
22.73
Human Site:
Y253
Identified Species:
45.45
UniProt:
Q8IZD6
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IZD6
NP_060890.2
547
60540
Y253
P
E
S
P
R
W
L
Y
S
Q
G
R
L
S
E
Chimpanzee
Pan troglodytes
XP_524810
547
60491
Y253
P
E
S
P
R
W
L
Y
S
Q
G
R
L
S
E
Rhesus Macaque
Macaca mulatta
XP_001112207
547
60489
Y253
P
E
S
P
R
W
L
Y
S
Q
G
R
L
S
E
Dog
Lupus familis
XP_540254
585
64648
Y291
P
E
S
P
R
W
L
Y
S
Q
G
R
L
S
E
Cat
Felis silvestris
Mouse
Mus musculus
Q504N2
544
60273
Y253
P
E
S
P
R
W
L
Y
S
Q
G
R
L
S
E
Rat
Rattus norvegicus
O70594
557
62549
R254
P
L
F
A
Y
F
I
R
D
W
R
M
L
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510903
488
53593
A202
S
L
T
N
V
T
F
A
V
G
I
A
F
Y
A
Chicken
Gallus gallus
XP_416558
546
60154
Y253
P
E
S
P
R
W
L
Y
S
Q
G
R
L
S
E
Frog
Xenopus laevis
Q6NUB3
531
58000
Q245
S
P
R
W
L
Y
A
Q
G
R
L
H
E
A
Q
Zebra Danio
Brachydanio rerio
NP_001103169
497
54650
P210
L
A
T
A
A
N
C
P
G
L
L
L
F
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCA2
548
60985
L256
A
I
T
L
P
G
L
L
F
L
C
Y
Y
W
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U539
585
65444
V296
P
E
S
P
R
W
S
V
S
V
G
K
W
A
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
84.4
N.A.
93.4
31.4
N.A.
43.6
87.1
58.3
45.3
N.A.
33.3
N.A.
25.9
N.A.
Protein Similarity:
100
99.8
99.6
89
N.A.
96.8
52.4
N.A.
58.3
92.5
75.1
65.2
N.A.
54.2
N.A.
48.7
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
13.3
N.A.
0
100
0
0
N.A.
6.6
N.A.
53.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
6.6
100
26.6
6.6
N.A.
13.3
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
17
9
0
9
9
0
0
0
9
0
17
9
% A
% Cys:
0
0
0
0
0
0
9
0
0
0
9
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
9
% D
% Glu:
0
59
0
0
0
0
0
0
0
0
0
0
9
0
50
% E
% Phe:
0
0
9
0
0
9
9
0
9
0
0
0
17
0
0
% F
% Gly:
0
0
0
0
0
9
0
0
17
9
59
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% H
% Ile:
0
9
0
0
0
0
9
0
0
0
9
0
0
0
9
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% K
% Leu:
9
17
0
9
9
0
59
9
0
17
17
9
59
17
17
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% M
% Asn:
0
0
0
9
0
9
0
0
0
0
0
0
0
0
0
% N
% Pro:
67
9
0
59
9
0
0
9
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
9
0
50
0
0
0
0
9
% Q
% Arg:
0
0
9
0
59
0
0
9
0
9
9
50
0
0
0
% R
% Ser:
17
0
59
0
0
0
9
0
59
0
0
0
0
50
0
% S
% Thr:
0
0
25
0
0
9
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
9
0
0
9
9
9
0
0
0
0
0
% V
% Trp:
0
0
0
9
0
59
0
0
0
9
0
0
9
9
0
% W
% Tyr:
0
0
0
0
9
9
0
50
0
0
0
9
9
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _