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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
XRN1
All Species:
13.33
Human Site:
S1387
Identified Species:
36.67
UniProt:
Q8IZH2
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IZH2
NP_001036069.1
1706
194107
S1387
I
A
N
E
I
P
V
S
S
N
R
R
D
E
Y
Chimpanzee
Pan troglodytes
XP_001161640
1705
193944
S1387
I
A
N
E
I
P
I
S
S
N
R
R
D
E
Y
Rhesus Macaque
Macaca mulatta
XP_001112305
1706
193938
S1387
I
G
N
E
I
P
V
S
S
I
R
R
D
E
Y
Dog
Lupus familis
XP_852437
1705
193966
S1387
F
G
N
E
V
T
V
S
S
N
R
R
D
E
Y
Cat
Felis silvestris
Mouse
Mus musculus
P97789
1719
194289
K1399
R
M
L
K
E
I
L
K
I
D
S
P
D
T
R
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZIP4
949
108524
A642
D
L
N
G
K
K
Y
A
W
Q
G
V
A
L
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957327
1697
190923
E1387
K
G
T
L
V
L
K
E
M
L
K
I
D
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393481
1633
188195
S1323
S
A
Q
E
H
Q
Q
S
G
V
C
K
T
P
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P22147
1528
175441
N1221
F
G
G
R
L
R
T
N
R
G
L
G
L
D
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
97.6
93.7
N.A.
86.6
N.A.
N.A.
N.A.
22.4
N.A.
62.7
N.A.
N.A.
37.8
N.A.
N.A.
Protein Similarity:
100
99.5
98.8
96.1
N.A.
91.6
N.A.
N.A.
N.A.
34.8
N.A.
75.2
N.A.
N.A.
55.5
N.A.
N.A.
P-Site Identity:
100
93.3
86.6
73.3
N.A.
6.6
N.A.
N.A.
N.A.
6.6
N.A.
6.6
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
100
100
86.6
80
N.A.
26.6
N.A.
N.A.
N.A.
13.3
N.A.
20
N.A.
N.A.
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
23.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
42
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
34
0
0
0
0
0
12
0
0
0
0
12
0
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% C
% Asp:
12
0
0
0
0
0
0
0
0
12
0
0
67
12
0
% D
% Glu:
0
0
0
56
12
0
0
12
0
0
0
0
0
45
0
% E
% Phe:
23
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
45
12
12
0
0
0
0
12
12
12
12
0
0
0
% G
% His:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
34
0
0
0
34
12
12
0
12
12
0
12
0
0
0
% I
% Lys:
12
0
0
12
12
12
12
12
0
0
12
12
0
0
12
% K
% Leu:
0
12
12
12
12
12
12
0
0
12
12
0
12
12
12
% L
% Met:
0
12
0
0
0
0
0
0
12
0
0
0
0
0
0
% M
% Asn:
0
0
56
0
0
0
0
12
0
34
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
34
0
0
0
0
0
12
0
12
0
% P
% Gln:
0
0
12
0
0
12
12
0
0
12
0
0
0
0
0
% Q
% Arg:
12
0
0
12
0
12
0
0
12
0
45
45
0
0
12
% R
% Ser:
12
0
0
0
0
0
0
56
45
0
12
0
0
12
12
% S
% Thr:
0
0
12
0
0
12
12
0
0
0
0
0
12
12
0
% T
% Val:
0
0
0
0
23
0
34
0
0
12
0
12
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
45
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _