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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
XRN1
All Species:
26.97
Human Site:
Y14
Identified Species:
74.17
UniProt:
Q8IZH2
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IZH2
NP_001036069.1
1706
194107
Y14
Y
R
W
I
S
E
R
Y
P
C
L
S
E
V
V
Chimpanzee
Pan troglodytes
XP_001161640
1705
193944
Y14
Y
R
W
I
S
E
R
Y
P
C
L
S
E
V
V
Rhesus Macaque
Macaca mulatta
XP_001112305
1706
193938
Y14
Y
R
W
I
S
E
R
Y
P
C
L
S
E
V
V
Dog
Lupus familis
XP_852437
1705
193966
Y14
Y
R
W
I
S
E
R
Y
P
C
L
S
E
V
V
Cat
Felis silvestris
Mouse
Mus musculus
P97789
1719
194289
Y14
Y
R
W
I
S
E
R
Y
P
C
L
S
E
V
V
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZIP4
949
108524
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957327
1697
190923
Y14
Y
R
W
I
S
E
R
Y
P
C
L
S
E
V
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393481
1633
188195
Y14
F
R
Y
I
N
E
R
Y
P
C
L
T
E
K
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P22147
1528
175441
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
97.6
93.7
N.A.
86.6
N.A.
N.A.
N.A.
22.4
N.A.
62.7
N.A.
N.A.
37.8
N.A.
N.A.
Protein Similarity:
100
99.5
98.8
96.1
N.A.
91.6
N.A.
N.A.
N.A.
34.8
N.A.
75.2
N.A.
N.A.
55.5
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
N.A.
N.A.
N.A.
0
N.A.
100
N.A.
N.A.
60
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
N.A.
0
N.A.
100
N.A.
N.A.
93.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
23.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
42
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
78
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
78
0
0
0
0
0
0
78
0
0
% E
% Phe:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
78
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
78
0
0
0
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
78
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
78
0
0
0
0
78
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
67
0
0
0
0
0
0
67
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
67
67
% V
% Trp:
0
0
67
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
67
0
12
0
0
0
0
78
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _