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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
XRN1
All Species:
18.18
Human Site:
Y433
Identified Species:
50
UniProt:
Q8IZH2
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IZH2
NP_001036069.1
1706
194107
Y433
F
E
T
E
F
R
Q
Y
K
R
T
Y
Y
M
T
Chimpanzee
Pan troglodytes
XP_001161640
1705
193944
Y433
F
E
T
E
F
R
Q
Y
K
R
T
Y
Y
M
T
Rhesus Macaque
Macaca mulatta
XP_001112305
1706
193938
Y433
F
E
T
E
F
R
Q
Y
K
R
T
Y
Y
M
T
Dog
Lupus familis
XP_852437
1705
193966
Y433
F
E
T
E
F
R
Q
Y
K
R
T
Y
Y
M
T
Cat
Felis silvestris
Mouse
Mus musculus
P97789
1719
194289
Y433
F
E
T
E
F
R
Q
Y
K
R
T
Y
Y
M
T
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZIP4
949
108524
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957327
1697
190923
Q434
M
F
E
T
E
F
R
Q
Y
K
R
T
Y
Y
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393481
1633
188195
C433
Y
T
M
E
F
V
Q
C
K
K
D
Y
Y
I
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P22147
1528
175441
E365
E
W
F
N
K
Q
L
E
N
I
S
L
E
G
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
97.6
93.7
N.A.
86.6
N.A.
N.A.
N.A.
22.4
N.A.
62.7
N.A.
N.A.
37.8
N.A.
N.A.
Protein Similarity:
100
99.5
98.8
96.1
N.A.
91.6
N.A.
N.A.
N.A.
34.8
N.A.
75.2
N.A.
N.A.
55.5
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
N.A.
N.A.
N.A.
0
N.A.
6.6
N.A.
N.A.
40
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
N.A.
0
N.A.
20
N.A.
N.A.
60
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
23.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
42
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% D
% Glu:
12
56
12
67
12
0
0
12
0
0
0
0
12
0
12
% E
% Phe:
56
12
12
0
67
12
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
12
0
0
0
12
0
% I
% Lys:
0
0
0
0
12
0
0
0
67
23
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
12
0
0
0
0
12
0
0
0
% L
% Met:
12
0
12
0
0
0
0
0
0
0
0
0
0
56
12
% M
% Asn:
0
0
0
12
0
0
0
0
12
0
0
0
0
0
12
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
12
67
12
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
56
12
0
0
56
12
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% S
% Thr:
0
12
56
12
0
0
0
0
0
0
56
12
0
0
56
% T
% Val:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
12
0
0
0
0
0
0
56
12
0
0
67
78
12
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _