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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UNC5B All Species: 18.79
Human Site: T446 Identified Species: 41.33
UniProt: Q8IZJ1 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IZJ1 NP_734465.2 945 103638 T446 P S V P P D L T A S A G I Y R
Chimpanzee Pan troglodytes XP_001164941 951 105434 L456 F H F T P Y L L A V P P D L T
Rhesus Macaque Macaca mulatta XP_001106162 1131 123665 T632 P S V P P D L T A S A G I Y R
Dog Lupus familis XP_850428 945 103644 T446 P S V P P D L T A S A G I Y R
Cat Felis silvestris
Mouse Mus musculus Q8K1S3 945 103720 T446 P S A P P D L T A S A G I Y R
Rat Rattus norvegicus O08722 945 103502 T446 P S A P P D L T A S A G I Y R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q7T2Z5 931 102888 K429 G F Q P V N I K A A R Q D L L
Frog Xenopus laevis Q8JGT4 943 105065 D447 I H P A M Q P D L T A N A G I
Zebra Danio Brachydanio rerio NP_001104619 940 103131 P442 D N P H L L H P T A P P D L T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95TU8 1072 116399 Y552 R S V M D A D Y M P G V V E K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q26261 919 101607 I411 G T L L G E K I S S C S Q Y F
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 63.8 81.4 95.6 N.A. 92.3 91.8 N.A. N.A. 63.7 78.8 66.9 N.A. 28.3 N.A. 27.9 N.A.
Protein Similarity: 100 77 81.9 98 N.A. 96.1 95.4 N.A. N.A. 76.6 88.8 79.8 N.A. 43.1 N.A. 45.7 N.A.
P-Site Identity: 100 20 100 100 N.A. 93.3 93.3 N.A. N.A. 13.3 6.6 0 N.A. 13.3 N.A. 13.3 N.A.
P-Site Similarity: 100 20 100 100 N.A. 93.3 93.3 N.A. N.A. 33.3 13.3 13.3 N.A. 26.6 N.A. 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 19 10 0 10 0 0 64 19 55 0 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % C
% Asp: 10 0 0 0 10 46 10 10 0 0 0 0 28 0 0 % D
% Glu: 0 0 0 0 0 10 0 0 0 0 0 0 0 10 0 % E
% Phe: 10 10 10 0 0 0 0 0 0 0 0 0 0 0 10 % F
% Gly: 19 0 0 0 10 0 0 0 0 0 10 46 0 10 0 % G
% His: 0 19 0 10 0 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 0 0 0 0 10 10 0 0 0 0 46 0 10 % I
% Lys: 0 0 0 0 0 0 10 10 0 0 0 0 0 0 10 % K
% Leu: 0 0 10 10 10 10 55 10 10 0 0 0 0 28 10 % L
% Met: 0 0 0 10 10 0 0 0 10 0 0 0 0 0 0 % M
% Asn: 0 10 0 0 0 10 0 0 0 0 0 10 0 0 0 % N
% Pro: 46 0 19 55 55 0 10 10 0 10 19 19 0 0 0 % P
% Gln: 0 0 10 0 0 10 0 0 0 0 0 10 10 0 0 % Q
% Arg: 10 0 0 0 0 0 0 0 0 0 10 0 0 0 46 % R
% Ser: 0 55 0 0 0 0 0 0 10 55 0 10 0 0 0 % S
% Thr: 0 10 0 10 0 0 0 46 10 10 0 0 0 0 19 % T
% Val: 0 0 37 0 10 0 0 0 0 10 0 10 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 10 0 10 0 0 0 0 0 55 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _