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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCOLN2
All Species:
17.58
Human Site:
Y510
Identified Species:
55.24
UniProt:
Q8IZK6
Number Species:
7
Phosphosite Substitution
Charge Score:
0.43
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IZK6
NP_694991.2
566
65942
Y510
I
A
L
I
T
D
S
Y
D
T
I
K
K
F
Q
Chimpanzee
Pan troglodytes
XP_513523
566
65804
Y510
I
A
L
I
T
D
S
Y
D
T
I
K
K
F
Q
Rhesus Macaque
Macaca mulatta
XP_001107980
566
65983
Y510
I
A
L
I
T
D
S
Y
D
T
I
K
K
F
Q
Dog
Lupus familis
XP_547307
544
63080
D489
A
L
I
T
D
S
Y
D
T
I
K
K
Y
Q
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8K595
566
65431
Y510
I
A
L
I
T
D
S
Y
H
T
I
K
K
Y
Q
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510269
539
62588
D484
A
L
I
T
D
S
Y
D
T
I
K
K
Y
Q
Q
Chicken
Gallus gallus
XP_422368
554
63749
D498
L
F
I
A
L
I
T
D
A
Y
D
T
I
K
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957442
561
64677
Y499
I
A
L
I
T
D
A
Y
E
T
I
K
G
Y
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.8
87.8
N.A.
80.7
N.A.
N.A.
80
73.1
N.A.
58.1
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.7
91.5
N.A.
88.6
N.A.
N.A.
86.5
84.2
N.A.
74.7
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
13.3
N.A.
86.6
N.A.
N.A.
13.3
0
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
93.3
N.A.
N.A.
20
26.6
N.A.
93.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
63
0
13
0
0
13
0
13
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
25
63
0
38
38
0
13
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% E
% Phe:
0
13
0
0
0
0
0
0
0
0
0
0
0
38
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% G
% His:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% H
% Ile:
63
0
38
63
0
13
0
0
0
25
63
0
13
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
25
88
50
13
13
% K
% Leu:
13
25
63
0
13
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
25
88
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
25
50
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
25
63
0
13
0
25
63
0
13
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
25
63
0
13
0
0
25
25
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _