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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX5
All Species:
6.06
Human Site:
S268
Identified Species:
13.33
UniProt:
Q8N196
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N196
NP_787071
739
74562
S268
G
G
G
A
P
C
K
S
E
S
D
G
N
P
T
Chimpanzee
Pan troglodytes
XP_512758
709
71738
P244
K
S
E
S
D
G
N
P
T
T
E
D
E
S
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855072
565
57177
A135
L
R
A
R
A
L
V
A
F
Q
R
G
E
Y
A
Cat
Felis silvestris
Mouse
Mus musculus
P70178
719
73699
S261
G
G
G
A
P
C
K
S
E
S
D
G
N
P
T
Rat
Rattus norvegicus
NP_001100209
705
75711
S246
S
D
G
V
T
N
L
S
L
S
S
H
M
E
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
O93307
246
27619
Frog
Xenopus laevis
Q9YGK8
467
50639
A37
A
A
A
A
A
A
A
A
A
A
A
A
G
S
G
Zebra Danio
Brachydanio rerio
NP_571795
797
83617
Q279
G
A
P
C
G
T
G
Q
L
V
L
N
S
P
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
Honey Bee
Apis mellifera
XP_396811
512
55470
S82
G
S
N
G
Q
L
S
S
F
G
F
T
Q
E
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781616
565
61026
V135
T
L
Q
N
D
E
T
V
L
R
A
R
A
A
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.5
N.A.
70.7
N.A.
85.9
32.3
N.A.
N.A.
20.4
21.5
34.8
N.A.
26.6
28.2
N.A.
30.5
Protein Similarity:
100
95.8
N.A.
71.5
N.A.
88.2
47.2
N.A.
N.A.
24.4
31.6
49.4
N.A.
34.7
38.9
N.A.
41.4
P-Site Identity:
100
0
N.A.
6.6
N.A.
100
20
N.A.
N.A.
0
6.6
13.3
N.A.
0
13.3
N.A.
0
P-Site Similarity:
100
26.6
N.A.
13.3
N.A.
100
20
N.A.
N.A.
0
20
20
N.A.
0
13.3
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
19
19
28
19
10
10
19
10
10
19
10
10
10
10
% A
% Cys:
0
0
0
10
0
19
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
19
0
0
0
0
0
19
10
0
0
0
% D
% Glu:
0
0
10
0
0
10
0
0
19
0
10
0
19
19
0
% E
% Phe:
0
0
0
0
0
0
0
0
19
0
10
0
0
0
0
% F
% Gly:
37
19
28
10
10
10
10
0
0
10
0
28
10
0
19
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
0
0
0
0
0
19
0
0
0
0
0
0
0
0
% K
% Leu:
10
10
0
0
0
19
10
0
28
0
10
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% M
% Asn:
0
0
10
10
0
10
10
0
0
0
0
10
19
0
0
% N
% Pro:
0
0
10
0
19
0
0
10
0
0
0
0
0
28
10
% P
% Gln:
0
0
10
0
10
0
0
10
0
10
0
0
10
0
10
% Q
% Arg:
0
10
0
10
0
0
0
0
0
10
10
10
0
0
0
% R
% Ser:
10
19
0
10
0
0
10
37
0
28
10
0
10
19
10
% S
% Thr:
10
0
0
0
10
10
10
0
10
10
0
10
0
0
19
% T
% Val:
0
0
0
10
0
0
10
10
0
10
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _