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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX5
All Species:
6.67
Human Site:
S354
Identified Species:
14.67
UniProt:
Q8N196
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N196
NP_787071
739
74562
S354
G
L
A
L
G
E
A
S
S
L
G
P
L
L
L
Chimpanzee
Pan troglodytes
XP_512758
709
71738
S324
G
L
A
L
G
E
A
S
S
L
G
P
L
L
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855072
565
57177
A215
C
F
K
E
R
S
R
A
A
L
K
A
C
Y
R
Cat
Felis silvestris
Mouse
Mus musculus
P70178
719
73699
N346
N
S
L
A
L
G
E
N
S
S
L
G
P
L
L
Rat
Rattus norvegicus
NP_001100209
705
75711
I328
S
N
T
V
G
N
G
I
A
M
T
D
I
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
O93307
246
27619
Frog
Xenopus laevis
Q9YGK8
467
50639
Y117
A
H
T
T
P
G
Y
Y
P
Y
G
Q
F
Q
Y
Zebra Danio
Brachydanio rerio
NP_571795
797
83617
T359
L
E
A
Q
G
S
L
T
T
V
V
L
N
P
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
G66
D
I
M
A
H
N
G
G
G
A
G
G
G
L
H
Honey Bee
Apis mellifera
XP_396811
512
55470
L162
N
H
Q
K
L
Q
A
L
W
L
K
A
H
Y
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781616
565
61026
Y215
W
D
G
E
E
M
A
Y
C
F
K
E
K
S
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.5
N.A.
70.7
N.A.
85.9
32.3
N.A.
N.A.
20.4
21.5
34.8
N.A.
26.6
28.2
N.A.
30.5
Protein Similarity:
100
95.8
N.A.
71.5
N.A.
88.2
47.2
N.A.
N.A.
24.4
31.6
49.4
N.A.
34.7
38.9
N.A.
41.4
P-Site Identity:
100
100
N.A.
6.6
N.A.
20
13.3
N.A.
N.A.
0
6.6
13.3
N.A.
13.3
13.3
N.A.
6.6
P-Site Similarity:
100
100
N.A.
20
N.A.
26.6
40
N.A.
N.A.
0
6.6
33.3
N.A.
20
26.6
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
28
19
0
0
37
10
19
10
0
19
0
0
0
% A
% Cys:
10
0
0
0
0
0
0
0
10
0
0
0
10
0
0
% C
% Asp:
10
10
0
0
0
0
0
0
0
0
0
10
0
0
0
% D
% Glu:
0
10
0
19
10
19
10
0
0
0
0
10
0
0
0
% E
% Phe:
0
10
0
0
0
0
0
0
0
10
0
0
10
0
0
% F
% Gly:
19
0
10
0
37
19
19
10
10
0
37
19
10
0
10
% G
% His:
0
19
0
0
10
0
0
0
0
0
0
0
10
0
10
% H
% Ile:
0
10
0
0
0
0
0
10
0
0
0
0
10
0
10
% I
% Lys:
0
0
10
10
0
0
0
0
0
0
28
0
10
0
0
% K
% Leu:
10
19
10
19
19
0
10
10
0
37
10
10
19
46
28
% L
% Met:
0
0
10
0
0
10
0
0
0
10
0
0
0
0
0
% M
% Asn:
19
10
0
0
0
19
0
10
0
0
0
0
10
0
0
% N
% Pro:
0
0
0
0
10
0
0
0
10
0
0
19
10
10
0
% P
% Gln:
0
0
10
10
0
10
0
0
0
0
0
10
0
10
10
% Q
% Arg:
0
0
0
0
10
0
10
0
0
0
0
0
0
0
19
% R
% Ser:
10
10
0
0
0
19
0
19
28
10
0
0
0
10
0
% S
% Thr:
0
0
19
10
0
0
0
10
10
0
10
0
0
0
0
% T
% Val:
0
0
0
10
0
0
0
0
0
10
10
0
0
0
0
% V
% Trp:
10
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
19
0
10
0
0
0
19
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _