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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX5
All Species:
9.09
Human Site:
S373
Identified Species:
20
UniProt:
Q8N196
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N196
NP_787071
739
74562
S373
G
A
P
P
P
Q
P
S
P
Q
G
A
S
E
T
Chimpanzee
Pan troglodytes
XP_512758
709
71738
S343
G
A
P
P
P
Q
P
S
P
Q
G
A
S
E
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855072
565
57177
R234
P
T
P
D
E
K
R
R
L
A
T
L
T
G
L
Cat
Felis silvestris
Mouse
Mus musculus
P70178
719
73699
S365
S
A
P
Q
P
Q
P
S
L
Q
G
V
S
E
A
Rat
Rattus norvegicus
NP_001100209
705
75711
L347
D
V
K
E
F
K
V
L
Q
S
S
A
V
N
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
O93307
246
27619
Frog
Xenopus laevis
Q9YGK8
467
50639
E136
R
P
K
N
A
T
R
E
S
T
G
T
L
K
A
Zebra Danio
Brachydanio rerio
NP_571795
797
83617
S378
S
T
I
P
L
S
L
S
E
D
T
K
S
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
G85
S
N
G
G
G
G
G
G
V
V
S
G
G
G
S
Honey Bee
Apis mellifera
XP_396811
512
55470
A181
L
R
G
R
P
L
G
A
V
G
K
Y
R
V
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781616
565
61026
Y234
E
C
Y
K
Q
N
R
Y
P
T
P
D
E
K
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.5
N.A.
70.7
N.A.
85.9
32.3
N.A.
N.A.
20.4
21.5
34.8
N.A.
26.6
28.2
N.A.
30.5
Protein Similarity:
100
95.8
N.A.
71.5
N.A.
88.2
47.2
N.A.
N.A.
24.4
31.6
49.4
N.A.
34.7
38.9
N.A.
41.4
P-Site Identity:
100
93.3
N.A.
6.6
N.A.
66.6
6.6
N.A.
N.A.
0
6.6
20
N.A.
0
6.6
N.A.
6.6
P-Site Similarity:
100
93.3
N.A.
20
N.A.
66.6
20
N.A.
N.A.
0
13.3
26.6
N.A.
6.6
13.3
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
28
0
0
10
0
0
10
0
10
0
28
0
0
28
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
10
0
0
0
0
0
10
0
10
0
0
0
% D
% Glu:
10
0
0
10
10
0
0
10
10
0
0
0
10
28
0
% E
% Phe:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
19
0
19
10
10
10
19
10
0
10
37
10
10
19
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
19
10
0
19
0
0
0
0
10
10
0
19
0
% K
% Leu:
10
0
0
0
10
10
10
10
19
0
0
10
10
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
10
0
10
0
0
0
0
0
0
0
10
0
% N
% Pro:
10
10
37
28
37
0
28
0
28
0
10
0
0
0
0
% P
% Gln:
0
0
0
10
10
28
0
0
10
28
0
0
0
0
0
% Q
% Arg:
10
10
0
10
0
0
28
10
0
0
0
0
10
0
19
% R
% Ser:
28
0
0
0
0
10
0
37
10
10
19
0
37
0
28
% S
% Thr:
0
19
0
0
0
10
0
0
0
19
19
10
10
10
10
% T
% Val:
0
10
0
0
0
0
10
0
19
10
0
10
10
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
10
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _