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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GHDC All Species: 11.82
Human Site: T389 Identified Species: 28.89
UniProt: Q8N2G8 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8N2G8 NP_001136094.1 530 57523 T389 F I C R L D Q T L S V R G E D
Chimpanzee Pan troglodytes XP_001166343 530 57648 T389 F I C R L D Q T L S V R G E D
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_849480 529 57233 G388 F V R R L G Q G L N V R G E D
Cat Felis silvestris
Mouse Mus musculus Q99J23 532 58473 T390 F T C R L G Q T L N V R G E V
Rat Rattus norvegicus XP_220981 527 57849 T387 F T C R L G Q T L S V R G E V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418150 304 33827 P193 R R A V G M W P G A R L M D Y
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_795021 622 70275 L464 F L Y R Q G Q L L N L R G E K
Poplar Tree Populus trichocarpa XP_002319398 608 68779 V445 F V C R K N V V L S I D S D K
Maize Zea mays NP_001146837 610 66901 L448 F V R R K N V L L S I E S D K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LQ68 597 67028 L437 F I R R E N V L L S I E S D K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.4 N.A. 82.8 N.A. 73.5 74.1 N.A. N.A. 31.3 N.A. N.A. N.A. N.A. N.A. N.A. 24.4
Protein Similarity: 100 99.2 N.A. 86.7 N.A. 81.3 81.1 N.A. N.A. 40.1 N.A. N.A. N.A. N.A. N.A. N.A. 40.6
P-Site Identity: 100 100 N.A. 66.6 N.A. 73.3 80 N.A. N.A. 0 N.A. N.A. N.A. N.A. N.A. N.A. 46.6
P-Site Similarity: 100 100 N.A. 80 N.A. 80 80 N.A. N.A. 13.3 N.A. N.A. N.A. N.A. N.A. N.A. 66.6
Percent
Protein Identity: 22.2 26 N.A. 21.2 N.A. N.A.
Protein Similarity: 39.6 41.3 N.A. 40.2 N.A. N.A.
P-Site Identity: 33.3 26.6 N.A. 33.3 N.A. N.A.
P-Site Similarity: 60 53.3 N.A. 53.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 0 0 0 10 0 0 0 0 0 % A
% Cys: 0 0 50 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 20 0 0 0 0 0 10 0 40 30 % D
% Glu: 0 0 0 0 10 0 0 0 0 0 0 20 0 60 0 % E
% Phe: 90 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 10 40 0 10 10 0 0 0 60 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 30 0 0 0 0 0 0 0 0 30 0 0 0 0 % I
% Lys: 0 0 0 0 20 0 0 0 0 0 0 0 0 0 40 % K
% Leu: 0 10 0 0 50 0 0 30 90 0 10 10 0 0 0 % L
% Met: 0 0 0 0 0 10 0 0 0 0 0 0 10 0 0 % M
% Asn: 0 0 0 0 0 30 0 0 0 30 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 10 0 60 0 0 0 0 0 0 0 0 % Q
% Arg: 10 10 30 90 0 0 0 0 0 0 10 60 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 60 0 0 30 0 0 % S
% Thr: 0 20 0 0 0 0 0 40 0 0 0 0 0 0 0 % T
% Val: 0 30 0 10 0 0 30 10 0 0 50 0 0 0 20 % V
% Trp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _