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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GHDC All Species: 20
Human Site: Y312 Identified Species: 48.89
UniProt: Q8N2G8 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8N2G8 NP_001136094.1 530 57523 Y312 P E Q P H G L Y L L P P G A P
Chimpanzee Pan troglodytes XP_001166343 530 57648 Y312 P E Q P H G L Y L L P P G A P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_849480 529 57233 Y311 P E Q P R G L Y L L P P G A P
Cat Felis silvestris
Mouse Mus musculus Q99J23 532 58473 Y313 P E R P Q G S Y L L P P G V P
Rat Rattus norvegicus XP_220981 527 57849 Y310 P E Q P Q G S Y L L S P G V P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418150 304 33827 L119 E E Q H T A L L G E L W E G R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_795021 622 70275 Y388 P F D A E R R Y L L V P K S M
Poplar Tree Populus trichocarpa XP_002319398 608 68779 T356 K P S E V S Y T L I P T M A Y
Maize Zea mays NP_001146837 610 66901 N361 S E C Y F G L N L R P M C D P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LQ68 597 67028 Y358 C K P S E V S Y T I F P N M A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.4 N.A. 82.8 N.A. 73.5 74.1 N.A. N.A. 31.3 N.A. N.A. N.A. N.A. N.A. N.A. 24.4
Protein Similarity: 100 99.2 N.A. 86.7 N.A. 81.3 81.1 N.A. N.A. 40.1 N.A. N.A. N.A. N.A. N.A. N.A. 40.6
P-Site Identity: 100 100 N.A. 93.3 N.A. 73.3 73.3 N.A. N.A. 20 N.A. N.A. N.A. N.A. N.A. N.A. 33.3
P-Site Similarity: 100 100 N.A. 93.3 N.A. 80 73.3 N.A. N.A. 20 N.A. N.A. N.A. N.A. N.A. N.A. 40
Percent
Protein Identity: 22.2 26 N.A. 21.2 N.A. N.A.
Protein Similarity: 39.6 41.3 N.A. 40.2 N.A. N.A.
P-Site Identity: 20 40 N.A. 13.3 N.A. N.A.
P-Site Similarity: 26.6 40 N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 0 10 0 0 0 0 0 0 0 40 10 % A
% Cys: 10 0 10 0 0 0 0 0 0 0 0 0 10 0 0 % C
% Asp: 0 0 10 0 0 0 0 0 0 0 0 0 0 10 0 % D
% Glu: 10 70 0 10 20 0 0 0 0 10 0 0 10 0 0 % E
% Phe: 0 10 0 0 10 0 0 0 0 0 10 0 0 0 0 % F
% Gly: 0 0 0 0 0 60 0 0 10 0 0 0 50 10 0 % G
% His: 0 0 0 10 20 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 20 0 0 0 0 0 % I
% Lys: 10 10 0 0 0 0 0 0 0 0 0 0 10 0 0 % K
% Leu: 0 0 0 0 0 0 50 10 80 60 10 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 10 10 10 % M
% Asn: 0 0 0 0 0 0 0 10 0 0 0 0 10 0 0 % N
% Pro: 60 10 10 50 0 0 0 0 0 0 60 70 0 0 60 % P
% Gln: 0 0 50 0 20 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 10 0 10 10 10 0 0 10 0 0 0 0 10 % R
% Ser: 10 0 10 10 0 10 30 0 0 0 10 0 0 10 0 % S
% Thr: 0 0 0 0 10 0 0 10 10 0 0 10 0 0 0 % T
% Val: 0 0 0 0 10 10 0 0 0 0 10 0 0 20 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % W
% Tyr: 0 0 0 10 0 0 10 70 0 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _