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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL4
All Species:
20
Human Site:
S227
Identified Species:
40
UniProt:
Q8N3J2
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N3J2
NP_073751.3
472
54041
S227
Q
L
V
E
E
D
T
S
V
T
E
Q
D
L
F
Chimpanzee
Pan troglodytes
XP_523876
472
54094
S227
Q
L
V
E
E
D
T
S
V
T
E
Q
D
L
F
Rhesus Macaque
Macaca mulatta
XP_001087322
472
53974
S227
Q
L
V
E
E
D
T
S
V
T
E
Q
D
L
F
Dog
Lupus familis
XP_547656
471
53786
S227
Q
L
M
E
Q
D
I
S
V
T
E
Q
D
L
F
Cat
Felis silvestris
Mouse
Mus musculus
Q3U034
471
53288
S226
Q
L
M
G
D
D
V
S
V
I
E
L
D
L
S
Rat
Rattus norvegicus
XP_001056749
471
53369
F226
Q
L
M
G
D
D
V
F
V
T
E
L
D
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505366
465
51537
Q221
E
E
M
C
I
P
E
Q
D
L
F
S
R
V
T
Chicken
Gallus gallus
XP_419143
475
53647
T231
N
V
L
D
D
E
T
T
I
P
E
Q
D
L
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_689178
450
51428
L219
P
P
R
C
R
F
L
L
S
D
V
T
R
M
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_495127
365
42197
G134
L
S
N
L
M
S
N
G
M
I
N
N
W
V
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002327074
408
46952
M177
V
N
E
T
S
D
D
M
E
A
E
F
L
N
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8LFA9
414
47866
V183
Q
V
F
N
N
L
V
V
N
E
I
G
E
E
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
96.6
82.4
N.A.
75.2
75
N.A.
58.6
55.1
N.A.
42.3
N.A.
N.A.
N.A.
25.2
N.A.
Protein Similarity:
100
99.7
98
90.6
N.A.
84.7
86
N.A.
70.7
71.3
N.A.
58.4
N.A.
N.A.
N.A.
41.9
N.A.
P-Site Identity:
100
100
100
80
N.A.
53.3
53.3
N.A.
0
33.3
N.A.
0
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
66.6
66.6
N.A.
20
80
N.A.
6.6
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
25.6
N.A.
N.A.
26.9
N.A.
N.A.
Protein Similarity:
44
N.A.
N.A.
43.8
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% A
% Cys:
0
0
0
17
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
9
25
59
9
0
9
9
0
0
59
0
9
% D
% Glu:
9
9
9
34
25
9
9
0
9
9
67
0
9
9
0
% E
% Phe:
0
0
9
0
0
9
0
9
0
0
9
9
0
0
34
% F
% Gly:
0
0
0
17
0
0
0
9
0
0
0
9
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
9
0
9
0
9
17
9
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
9
50
9
9
0
9
9
9
0
9
0
17
9
59
9
% L
% Met:
0
0
34
0
9
0
0
9
9
0
0
0
0
9
0
% M
% Asn:
9
9
9
9
9
0
9
0
9
0
9
9
0
9
9
% N
% Pro:
9
9
0
0
0
9
0
0
0
9
0
0
0
0
0
% P
% Gln:
59
0
0
0
9
0
0
9
0
0
0
42
0
0
0
% Q
% Arg:
0
0
9
0
9
0
0
0
0
0
0
0
17
0
9
% R
% Ser:
0
9
0
0
9
9
0
42
9
0
0
9
0
0
17
% S
% Thr:
0
0
0
9
0
0
34
9
0
42
0
9
0
0
9
% T
% Val:
9
17
25
0
0
0
25
9
50
0
9
0
0
17
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _