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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL4
All Species:
30.91
Human Site:
Y343
Identified Species:
61.82
UniProt:
Q8N3J2
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N3J2
NP_073751.3
472
54041
Y343
R
F
I
K
E
E
L
Y
P
S
W
S
V
E
V
Chimpanzee
Pan troglodytes
XP_523876
472
54094
Y343
R
F
I
K
E
E
L
Y
P
S
W
S
V
E
V
Rhesus Macaque
Macaca mulatta
XP_001087322
472
53974
Y343
R
F
I
K
E
E
L
Y
P
S
W
S
V
E
V
Dog
Lupus familis
XP_547656
471
53786
Y343
R
F
V
K
E
E
L
Y
P
S
W
S
V
D
I
Cat
Felis silvestris
Mouse
Mus musculus
Q3U034
471
53288
Y342
C
F
V
K
E
E
L
Y
P
S
W
S
V
E
V
Rat
Rattus norvegicus
XP_001056749
471
53369
Y342
C
F
V
K
E
E
L
Y
P
S
W
S
V
E
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505366
465
51537
Y333
S
F
V
K
D
E
L
Y
P
C
W
S
V
E
T
Chicken
Gallus gallus
XP_419143
475
53647
Y347
R
F
V
K
D
E
L
Y
P
H
W
S
V
K
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_689178
450
51428
K329
P
L
D
S
Q
H
K
K
P
Y
E
V
L
V
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_495127
365
42197
R244
I
E
E
E
M
I
E
R
F
D
K
W
G
M
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002327074
408
46952
Y287
G
V
S
H
E
A
T
Y
Y
W
L
K
V
K
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8LFA9
414
47866
W293
E
K
E
L
F
P
A
W
G
I
K
Y
V
A
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
96.6
82.4
N.A.
75.2
75
N.A.
58.6
55.1
N.A.
42.3
N.A.
N.A.
N.A.
25.2
N.A.
Protein Similarity:
100
99.7
98
90.6
N.A.
84.7
86
N.A.
70.7
71.3
N.A.
58.4
N.A.
N.A.
N.A.
41.9
N.A.
P-Site Identity:
100
100
100
80
N.A.
86.6
86.6
N.A.
66.6
66.6
N.A.
6.6
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
80
86.6
N.A.
26.6
N.A.
N.A.
N.A.
6.6
N.A.
Percent
Protein Identity:
25.6
N.A.
N.A.
26.9
N.A.
N.A.
Protein Similarity:
44
N.A.
N.A.
43.8
N.A.
N.A.
P-Site Identity:
20
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
9
9
0
0
0
0
0
0
9
9
% A
% Cys:
17
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% C
% Asp:
0
0
9
0
17
0
0
0
0
9
0
0
0
9
0
% D
% Glu:
9
9
17
9
59
67
9
0
0
0
9
0
0
50
9
% E
% Phe:
0
67
0
0
9
0
0
0
9
0
0
0
0
0
0
% F
% Gly:
9
0
0
0
0
0
0
0
9
0
0
0
9
0
0
% G
% His:
0
0
0
9
0
9
0
0
0
9
0
0
0
0
0
% H
% Ile:
9
0
25
0
0
9
0
0
0
9
0
0
0
0
9
% I
% Lys:
0
9
0
67
0
0
9
9
0
0
17
9
0
17
0
% K
% Leu:
0
9
0
9
0
0
67
0
0
0
9
0
9
0
9
% L
% Met:
0
0
0
0
9
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
9
0
0
0
0
9
0
0
75
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
42
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% R
% Ser:
9
0
9
9
0
0
0
0
0
50
0
67
0
0
0
% S
% Thr:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
25
% T
% Val:
0
9
42
0
0
0
0
0
0
0
0
9
84
9
42
% V
% Trp:
0
0
0
0
0
0
0
9
0
9
67
9
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
75
9
9
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _