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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RASGEF1C All Species: 26.67
Human Site: Y441 Identified Species: 53.33
UniProt: Q8N431 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8N431 NP_778232.2 466 52870 Y441 D G L Y L A S Y E S E S P E N
Chimpanzee Pan troglodytes XP_518156 546 61226 Y521 D G L Y L A S Y E S E S P E N
Rhesus Macaque Macaca mulatta XP_001102791 466 52809 Y441 D G L Y L A S Y E S E S P E N
Dog Lupus familis XP_538583 684 76123 E508 D G S L L A M E G N V Q L D T
Cat Felis silvestris
Mouse Mus musculus Q9D300 466 52705 Y441 D G L Y L A S Y E S E S P E S
Rat Rattus norvegicus NP_001101743 466 52800 Y441 D G L Y L A S Y E S E S P E N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507622 522 60072 F497 E A L F V A S F E S E G P E N
Chicken Gallus gallus XP_414615 480 55173 Y455 D G L Y L A S Y E S E S P E N
Frog Xenopus laevis NP_001086251 419 48694 F394 E A L F L A S F E N E G P D N
Zebra Danio Brachydanio rerio Q6DHR3 514 59871 Y489 D A L Y L A S Y E S E G P E N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_396254 713 79278 L679 N P R V I A F L Q A R P V W T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789261 598 68657 L564 D R Q A L N Y L L T A P V F S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.1 98 63 N.A. 94.6 94.8 N.A. 51.3 81 50.4 62.8 N.A. N.A. 37.3 N.A. 44.4
Protein Similarity: 100 85.1 98.9 66.2 N.A. 97.4 97.4 N.A. 66 87.9 65.4 73.9 N.A. N.A. 48.3 N.A. 56.8
P-Site Identity: 100 100 100 26.6 N.A. 93.3 100 N.A. 60 100 53.3 86.6 N.A. N.A. 6.6 N.A. 13.3
P-Site Similarity: 100 100 100 40 N.A. 100 100 N.A. 86.6 100 86.6 86.6 N.A. N.A. 33.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 25 0 9 0 92 0 0 0 9 9 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 75 0 0 0 0 0 0 0 0 0 0 0 0 17 0 % D
% Glu: 17 0 0 0 0 0 0 9 75 0 75 0 0 67 0 % E
% Phe: 0 0 0 17 0 0 9 17 0 0 0 0 0 9 0 % F
% Gly: 0 59 0 0 0 0 0 0 9 0 0 25 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 75 9 84 0 0 17 9 0 0 0 9 0 0 % L
% Met: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % M
% Asn: 9 0 0 0 0 9 0 0 0 17 0 0 0 0 67 % N
% Pro: 0 9 0 0 0 0 0 0 0 0 0 17 75 0 0 % P
% Gln: 0 0 9 0 0 0 0 0 9 0 0 9 0 0 0 % Q
% Arg: 0 9 9 0 0 0 0 0 0 0 9 0 0 0 0 % R
% Ser: 0 0 9 0 0 0 75 0 0 67 0 50 0 0 17 % S
% Thr: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 17 % T
% Val: 0 0 0 9 9 0 0 0 0 0 9 0 17 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % W
% Tyr: 0 0 0 59 0 0 9 59 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _